TY  - JOUR
AU  - Avanzini, Pietro
AU  - Abdollahi, Rouhollah
AU  - Sartori, Ivana
AU  - Caruana, Fausto
AU  - Pelliccia, Veronica
AU  - Casaceli, Giuseppe
AU  - Mai, Roberto
AU  - Lo Russo, Giorgio
AU  - Rizzolatti, Giacomo
AU  - Orban, Guy A.
TI  - Four-dimensional maps of the human somatosensory system
JO  - Proceedings of the National Academy of Sciences of the United States of America
VL  - 113
IS  - 13
SN  - 1091-6490
CY  - Washington, DC
PB  - National Acad. of Sciences
M1  - FZJ-2016-07681
SP  - E1936 - E1943
PY  - 2016
AB  - A fine-grained description of the spatiotemporal dynamics of human brain activity is a major goal of neuroscientific research. Limitations in spatial and temporal resolution of available noninvasive recording and imaging techniques have hindered so far the acquisition of precise, comprehensive four-dimensional maps of human neural activity. The present study combines anatomical and functional data from intracerebral recordings of nearly 100 patients, to generate highly resolved four-dimensional maps of human cortical processing of nonpainful somatosensory stimuli. These maps indicate that the human somatosensory system devoted to the hand encompasses a widespread network covering more than 10% of the cortical surface of both hemispheres. This network includes phasic components, centered on primary somatosensory cortex and neighboring motor, premotor, and inferior parietal regions, and tonic components, centered on opercular and insular areas, and involving human parietal rostroventral area and ventral medial-superior-temporal area. The technique described opens new avenues for investigating the neural basis of all levels of cortical processing in humans.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000372876400022
C6  - pmid:26976579
DO  - DOI:10.1073/pnas.1601889113
UR  - https://juser.fz-juelich.de/record/825210
ER  -