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@ARTICLE{Bischof:825212,
      author       = {Bischof, Gérard N. and Rodrigue, Karen M. and Kennedy,
                      Kristen M. and Devous, Michael D. and Park, Denise C.},
      title        = {{A}myloid deposition in younger adults is linked to
                      episodic memory performance},
      journal      = {Neurology},
      volume       = {87},
      number       = {24},
      issn         = {1526-632X},
      address      = {Philadelphia, Pa.},
      publisher    = {Wolters Kluwer},
      reportid     = {FZJ-2016-07683},
      pages        = {2562 - 2566},
      year         = {2016},
      abstract     = {Objective: To examine the relationship of β-amyloid (Aβ)
                      deposition to episodic memory in younger (30–49 years),
                      middle-older (50–69 years), and older adults (70–89
                      years). We hypothesized that subclinical levels of amyloid
                      would be linked to memory in adults across the lifespan in a
                      dose-dependent fashion. Of great interest was whether,
                      within the younger group, a relationship between amyloid
                      level and memory performance could be established.Methods: A
                      total of 147 participants from the Dallas Lifespan Brain
                      Study, aged 30–89, underwent PET imaging with
                      18F-florbetapir and cognitive assessment. We assessed the
                      relationship between age group and amyloid and tested
                      whether Aβ differentially affected memory performance
                      across the 3 age groups.Results: We report a significant
                      association of age to amyloid burden for younger and
                      middle-older adults (r = 0.57 and 0.28, respectively), but
                      not for the oldest group, although absolute level of amyloid
                      increased across the age groups. Importantly, the youngest
                      group showed a significant decrease in recall (r = −0.47,
                      p = 0.004) and recognition memory (r = −0.48, p = 0.003)
                      as a function of increases in Aβ burden, whereas this
                      relationship was absent in the middle-older and oldest group
                      (all p > 0.23).Conclusions: These results indicate that
                      variance in subclinical levels of Aβ in younger adults is
                      meaningful, and suggest that higher SUVRs relative to one's
                      peers at a younger age is not entirely benign.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000392244200016},
      pubmed       = {pmid:27837001},
      doi          = {10.1212/WNL.0000000000003425},
      url          = {https://juser.fz-juelich.de/record/825212},
}