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| 001 | 825212 | ||
| 005 | 20210129225241.0 | ||
| 024 | 7 | _ | |a 10.1212/WNL.0000000000003425 |2 doi |
| 024 | 7 | _ | |a 0028-3878 |2 ISSN |
| 024 | 7 | _ | |a 1526-632X |2 ISSN |
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| 037 | _ | _ | |a FZJ-2016-07683 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Bischof, Gérard N. |0 P:(DE-Juel1)166265 |b 0 |e Corresponding author |u fzj |
| 245 | _ | _ | |a Amyloid deposition in younger adults is linked to episodic memory performance |
| 260 | _ | _ | |a Philadelphia, Pa. |c 2016 |b Wolters Kluwer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1482154792_5859 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Objective: To examine the relationship of β-amyloid (Aβ) deposition to episodic memory in younger (30–49 years), middle-older (50–69 years), and older adults (70–89 years). We hypothesized that subclinical levels of amyloid would be linked to memory in adults across the lifespan in a dose-dependent fashion. Of great interest was whether, within the younger group, a relationship between amyloid level and memory performance could be established.Methods: A total of 147 participants from the Dallas Lifespan Brain Study, aged 30–89, underwent PET imaging with 18F-florbetapir and cognitive assessment. We assessed the relationship between age group and amyloid and tested whether Aβ differentially affected memory performance across the 3 age groups.Results: We report a significant association of age to amyloid burden for younger and middle-older adults (r = 0.57 and 0.28, respectively), but not for the oldest group, although absolute level of amyloid increased across the age groups. Importantly, the youngest group showed a significant decrease in recall (r = −0.47, p = 0.004) and recognition memory (r = −0.48, p = 0.003) as a function of increases in Aβ burden, whereas this relationship was absent in the middle-older and oldest group (all p > 0.23).Conclusions: These results indicate that variance in subclinical levels of Aβ in younger adults is meaningful, and suggest that higher SUVRs relative to one's peers at a younger age is not entirely benign. |
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| 588 | _ | _ | |a Dataset connected to CrossRef |
| 700 | 1 | _ | |a Rodrigue, Karen M. |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Kennedy, Kristen M. |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Devous, Michael D. |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Park, Denise C. |0 P:(DE-HGF)0 |b 4 |
| 773 | _ | _ | |a 10.1212/WNL.0000000000003425 |g Vol. 87, no. 24, p. 2562 - 2566 |0 PERI:(DE-600)1491874-2 |n 24 |p 2562 - 2566 |t Neurology |v 87 |y 2016 |x 1526-632X |
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