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@ARTICLE{Grefkes:825216,
author = {Grefkes, Christian and Fink, Gereon R.},
title = {{N}oninvasive brain stimulation after stroke},
journal = {Current opinion in neurology},
volume = {29},
number = {6},
issn = {1350-7540},
address = {London},
publisher = {Lippincott Williams $\&$ Wilkins},
reportid = {FZJ-2016-07687},
pages = {714 - 720},
year = {2016},
abstract = {Purpose of review: We here provide an update about studies
published recently in the field of noninvasive
neuromodulation of the motor system, aiming at facilitating
recovery of function after stroke.Recent findings: A number
of longitudinal studies have confirmed that repeated
stimulation of the motor cortex in combination with motor
training improves performance compared with control or sham
stimulation. In the early postacute stroke phase,
enhancement of ipsilesional motor cortex excitability by
means of repetitive transcranial magnetic stimulation (rTMS)
seems to be a well tolerated and effective strategy to
promote motor recovery. In contrast, recent studies suggest
that transcranial direct current stimulation (tDCS) in the
early poststroke phase does not facilitate motor recovery.
In the chronic phase, however, both rTMS and tDCS have been
shown to be beneficial when applied over several days
combined with training. Interestingly, bihemispheric
stimulation strategies (ipsilesional activation and
contralesional suppression) seem to constitute effective
protocols, especially when using rTMS.Summary: Noninvasive
brain stimulation seems to support motor recovery. However,
to date randomised controlled trials (RCTs) that are
sufficiently powered are lacking. Data suggest that the most
promising protocols should now be tested in RCTs with
sufficiently large samples taking into account the clinical
heterogeneity of stroke.},
cin = {INM-3},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406},
pnm = {572 - (Dys-)function and Plasticity (POF3-572)},
pid = {G:(DE-HGF)POF3-572},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000387353900007},
pubmed = {pmid:27648877},
doi = {10.1097/WCO.0000000000000395},
url = {https://juser.fz-juelich.de/record/825216},
}