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@ARTICLE{Loehrer:825233,
author = {Loehrer, Philipp Alexander and Nettersheim, Felix Sebastian
and Jung, Fabienne and Weber, Immo and Huber, Carlo and
Dembek, Till Anselm and Pelzer, Esther Annegret and Fink,
Gereon Rudolf and Tittgemeyer, Marc and Timmermann, Lars},
title = {{A}geing changes effective connectivity of motor networks
during bimanual finger coordination},
journal = {NeuroImage},
volume = {143},
issn = {1053-8119},
address = {Orlando, Fla.},
publisher = {Academic Press},
reportid = {FZJ-2016-07704},
pages = {325 - 342},
year = {2016},
abstract = {Bimanual finger coordination declines with age. However,
relatively little is known about the neurophysiological
alterations in the motor-system causing this decline. In the
present study, we used 128-channel electroencephalography
(EEG) to evaluate causal interactions of cortical,
motor-related brain areas. Right-handed young and elderly
subjects performed complex temporally and spatially coupled
as well as temporally coupled and spatially uncoupled finger
tappings. Employing dynamic causal modelling (DCM) for
induced responses, we inferred task-induced effective
connectivity within a core motor network comprising
bilateral primary motor cortex (M1), lateral premotor cortex
(lPM), supplementary motor area (SMA), and prefrontal cortex
(PFC).Behavioural analysis showed significantly increased
error rates and performance times for elderly subjects,
confirming that motor functions decrease with ageing.
Additionally, DCM analysis revealed that this age-related
decline can be associated with specific alterations of
interhemispheric and prefrontal to premotor connectivity.
Young and elderly subjects exhibited inhibitory left to
right M1-M1 coupling during performance of temporally and
spatially coupled movements. Effects of ageing on
interhemispheric connectivity particularly emerged when
movements became spatially uncoupled. Here, elderly
participants still expressed inhibitory left to right M1-M1
coupling, whereas no such connection was present in the
young. Furthermore, ageing affected prefrontal to premotor
connectivity. In all conditions, elderly subjects showed
significant couplings from left PFC to left lPM. In
contrast, young participants exhibited left PFC to SMA
connections.These results demonstrate that (i) in spatially
uncoupled movements interhemispheric M1-connectivity
increases with age and (ii) support the idea that ageing is
associated with enhanced lateral prefrontal to premotor
coupling (PFC to lPM) and hypoactivation of a medial pathway
(PFC to SMA) within the dominant hemisphere.},
cin = {INM-3},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406},
pnm = {572 - (Dys-)function and Plasticity (POF3-572)},
pid = {G:(DE-HGF)POF3-572},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000389683000029},
pubmed = {pmid:27616642},
doi = {10.1016/j.neuroimage.2016.09.014},
url = {https://juser.fz-juelich.de/record/825233},
}