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@ARTICLE{Loehrer:825233,
      author       = {Loehrer, Philipp Alexander and Nettersheim, Felix Sebastian
                      and Jung, Fabienne and Weber, Immo and Huber, Carlo and
                      Dembek, Till Anselm and Pelzer, Esther Annegret and Fink,
                      Gereon Rudolf and Tittgemeyer, Marc and Timmermann, Lars},
      title        = {{A}geing changes effective connectivity of motor networks
                      during bimanual finger coordination},
      journal      = {NeuroImage},
      volume       = {143},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2016-07704},
      pages        = {325 - 342},
      year         = {2016},
      abstract     = {Bimanual finger coordination declines with age. However,
                      relatively little is known about the neurophysiological
                      alterations in the motor-system causing this decline. In the
                      present study, we used 128-channel electroencephalography
                      (EEG) to evaluate causal interactions of cortical,
                      motor-related brain areas. Right-handed young and elderly
                      subjects performed complex temporally and spatially coupled
                      as well as temporally coupled and spatially uncoupled finger
                      tappings. Employing dynamic causal modelling (DCM) for
                      induced responses, we inferred task-induced effective
                      connectivity within a core motor network comprising
                      bilateral primary motor cortex (M1), lateral premotor cortex
                      (lPM), supplementary motor area (SMA), and prefrontal cortex
                      (PFC).Behavioural analysis showed significantly increased
                      error rates and performance times for elderly subjects,
                      confirming that motor functions decrease with ageing.
                      Additionally, DCM analysis revealed that this age-related
                      decline can be associated with specific alterations of
                      interhemispheric and prefrontal to premotor connectivity.
                      Young and elderly subjects exhibited inhibitory left to
                      right M1-M1 coupling during performance of temporally and
                      spatially coupled movements. Effects of ageing on
                      interhemispheric connectivity particularly emerged when
                      movements became spatially uncoupled. Here, elderly
                      participants still expressed inhibitory left to right M1-M1
                      coupling, whereas no such connection was present in the
                      young. Furthermore, ageing affected prefrontal to premotor
                      connectivity. In all conditions, elderly subjects showed
                      significant couplings from left PFC to left lPM. In
                      contrast, young participants exhibited left PFC to SMA
                      connections.These results demonstrate that (i) in spatially
                      uncoupled movements interhemispheric M1-connectivity
                      increases with age and (ii) support the idea that ageing is
                      associated with enhanced lateral prefrontal to premotor
                      coupling (PFC to lPM) and hypoactivation of a medial pathway
                      (PFC to SMA) within the dominant hemisphere.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000389683000029},
      pubmed       = {pmid:27616642},
      doi          = {10.1016/j.neuroimage.2016.09.014},
      url          = {https://juser.fz-juelich.de/record/825233},
}