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000825262 1001_ $$0P:(DE-HGF)0$$aKlein, Rebecca$$b0$$eCorresponding author
000825262 245__ $$aThe Neural Cell Adhesion Molecule-Derived (NCAM)-Peptide FG Loop (FGL) Mobilizes Endogenous Neural Stem Cells and Promotes Endogenous Regenerative Capacity after Stroke
000825262 260__ $$aBoston, MA [u.a.]$$bSpringer$$c2016
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000825262 520__ $$aThe neural cell adhesion molecule (NCAM)-derived peptide FG loop (FGL) modulates synaptogenesis, neurogenesis, and stem cell proliferation, enhances cognitive capacities, and conveys neuroprotection after stroke. Here we investigated the effect of subcutaneously injected FGL on cellular compartments affected by degeneration and regeneration after stroke due to middle cerebral artery occlusion (MCAO), namely endogenous neural stem cells (NSC), oligodendrocytes, and microglia. In addition to immunohistochemistry, we used non-invasive positron emission tomography (PET) imaging with the tracer [18F]-fluoro-L-thymidine ([18F]FLT) to visualize endogenous NSC in vivo. FGL significantly increased endogenous NSC mobilization in the neurogenic niches as evidenced by in vivo and ex vivo methods, and it induced remyelination. Moreover, FGL affected neuroinflammation. Extending previous in vitro results, our data show that the NCAM mimetic peptide FGL mobilizes endogenous NSC after focal ischemia and enhances regeneration by amplifying remyelination and modulating neuroinflammation via affecting microglia. Results suggest FGL as a promising candidate to promote recovery after stroke.
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000825262 7001_ $$0P:(DE-HGF)0$$aMahlberg, Nicolas$$b1
000825262 7001_ $$0P:(DE-HGF)0$$aOhren, Maurice$$b2
000825262 7001_ $$0P:(DE-HGF)0$$aLadwig, Anne$$b3
000825262 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b4
000825262 7001_ $$0P:(DE-HGF)0$$aGraf, Rudolf$$b5
000825262 7001_ $$0P:(DE-HGF)0$$aHoehn, Mathias$$b6
000825262 7001_ $$0P:(DE-HGF)0$$aAlbrechtsen, Morten$$b7
000825262 7001_ $$0P:(DE-HGF)0$$aRees, Stephen$$b8
000825262 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b9
000825262 7001_ $$0P:(DE-HGF)0$$aRueger, Maria Adele$$b10
000825262 7001_ $$0P:(DE-HGF)0$$aSchroeter, Michael$$b11
000825262 773__ $$0PERI:(DE-600)2227405-4$$a10.1007/s11481-016-9694-5$$gVol. 11, no. 4, p. 708 - 720$$n4$$p708 - 720$$tJournal of neuroImmune pharmacology$$v11$$x1557-1904$$y2016
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