% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Elmenhorst:825265,
      author       = {Elmenhorst, David and Mertens, Kristina and Kroll, Tina and
                      Oskamp, Angela and Ermert, Johannes and Elmenhorst,
                      Eva-Maria and Wedekind, Franziska and Beer, Simone and
                      Coenen, Heinz H. and Bauer, Andreas},
      title        = {{C}ircadian variation of metabotropic glutamate receptor 5
                      availability in the rat brain},
      journal      = {Journal of sleep research},
      volume       = {25},
      number       = {6},
      issn         = {0962-1105},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2016-07736},
      pages        = {754 - 761},
      year         = {2016},
      abstract     = {The metabotrophic subtype 5 glutamate receptor (mGluR5)
                      plays a critical role in synaptic plasticity besides its
                      involvement in numerous neurological disorders, such as
                      depression. As mGluR5 availability in humans is altered in
                      sleep deprivation, we hypothesized that mGluR5 availability
                      underlies a circadian variation. To investigate whether
                      mGluR5 underlies potential circadian changes we measured its
                      density in a randomized fashion at six different daytimes in
                      11 adult Sprague–Dawley rats. mGluR5 density was
                      quantified by positron emission tomography (PET) using the
                      radioactive ligand [11C]ABP688. [11C]ABP688 uptake was
                      quantified in nine regions of interest with a reference
                      tissue model. Significant differences in the binding
                      potential (BPND) and therefore mGluR5 availability between
                      the different circadian times were found in cortex,
                      cingulate cortex, amygdala, caudate putamen and nucleus
                      accumbens. Further post-hoc statistical analysis
                      (Tukey–Kramer test) of the different time-points revealed
                      significant changes in BPND between 07:00 hours (start of
                      light-on phase) and 15:00 hours (last time-point of the
                      light-on phase) in the caudate putamen. This study shows
                      that mGluR5 availability is increased during the light-on,
                      or sleep phase, of rodents by approximately $10\%.$ Given
                      that altered mGluR5 densities play a role in psychiatric
                      disorders, further investigation is warranted to evaluate
                      their circadian involvement in mood changes in humans.},
      cin          = {INM-2 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000393032300018},
      pubmed       = {pmid:27357735},
      doi          = {10.1111/jsr.12432},
      url          = {https://juser.fz-juelich.de/record/825265},
}