000825273 001__ 825273
000825273 005__ 20210129225251.0
000825273 037__ $$aFZJ-2016-07744
000825273 041__ $$aEnglish
000825273 1001_ $$0P:(DE-Juel1)157902$$aVanasschen, Christian$$b0$$eCorresponding author$$ufzj
000825273 1112_ $$a21st International Symposium on Radiopharmaceutical Sciences$$cColumbia$$d2015-05-26 - 2015-05-31$$gISRS 2015$$wUSA
000825273 245__ $$aAuthentically radiolabelled Mn(II) complexes as bimodal PET/MR tracers
000825273 260__ $$c2015
000825273 3367_ $$033$$2EndNote$$aConference Paper
000825273 3367_ $$2BibTeX$$aINPROCEEDINGS
000825273 3367_ $$2DRIVER$$aconferenceObject
000825273 3367_ $$2ORCID$$aCONFERENCE_POSTER
000825273 3367_ $$2DataCite$$aOutput Types/Conference Poster
000825273 3367_ $$0PUB:(DE-HGF)24$$2PUB:(DE-HGF)$$aPoster$$bposter$$mposter$$s1482503773_29337$$xPlenary/Keynote
000825273 520__ $$aObjectives: Hybrid PET/MR imaging will pave the way for a better understanding of physiological and disease mechanisms in preclinical and clinical settings. Authentic radiolabeling of MR contrast agents ensures a fast and simple access to such bimodal tracers. In this case, a ligand chelating a paramagnetic metal ion (e.g. Mn) spiked with the authentic PET isotope (such as 52gMn) leads to a labelled molecule which can be detected with both imaging modalities. Paramagnetic [55Mn(CDTA)]2- shows an excellent compromise between thermodynamic stability, kinetic inertness and MR contrast enhancement [1]. The aim of this work was a proof of principle study of cyclohexanediaminetetraacetic acid (CDTA) ligands as prosthetic groups for Mn-labelled PET/MR tracers.Methods: N.c.a. 52gMn [t1/2: 5.6 d; Eβ+: 575.8 keV (29.6%)] was produced by proton irradiation of a natCr target and purified by cation-exchange chromatography [2]. CDTA radiolabeling with n.c.a. 52gMn2+ was performed in NaOAc buffer (1M, pH 6) at RT and monitored by radio-TLC as well as IC. Purification of the complex was performed by RP-HPLC and a test on stability in NaOAc buffer. A hydroxyalkyl functionalized CDTA ligand was synthesized starting from 3-cyclohexene-1-methanol in 5 steps.Results: The quantitative formation of [52gMn(CDTA)]2- was observed already within 30 min at RT. The complex was stable for at least 48 h at 50 °C. If an isotopic 52g/55Mn2+ mixture was applied the first prototypical manganese based bimodal PET/MR tracer was obtained. Furthermore, the hydroxyalkyl functionalized CDTA ligand was synthesized with an overall yield of 18-25%. Conclusions: Due to the hydrolytic stability and simple preparation of [52g/55Mn(CDTA)]2-, the CDTA ligand should be highly suitable for the preparation of manganese based PET/MR bimodal tracers. Acknowledgements: The authors thank M. Buchholz for production of 52gMnCl2.References: 	[1] Kalman, F. et al. (2012), Inorg. Chem., 51, 10065.[2] Buchholz, M. et al. (2013), Radiochim. Acta, 101, 491.
000825273 536__ $$0G:(DE-HGF)POF3-573$$a573 - Neuroimaging (POF3-573)$$cPOF3-573$$fPOF III$$x0
000825273 7001_ $$0P:(DE-Juel1)162273$$aBrandt, Marie$$b1$$ufzj
000825273 7001_ $$0P:(DE-Juel1)131818$$aErmert, Johannes$$b2$$ufzj
000825273 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b3$$ufzj
000825273 7001_ $$0P:(DE-Juel1)131816$$aCoenen, Heinrich Hubert$$b4$$ufzj
000825273 909CO $$ooai:juser.fz-juelich.de:825273$$pVDB
000825273 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)157902$$aForschungszentrum Jülich$$b0$$kFZJ
000825273 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)162273$$aForschungszentrum Jülich$$b1$$kFZJ
000825273 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131818$$aForschungszentrum Jülich$$b2$$kFZJ
000825273 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)166419$$aForschungszentrum Jülich$$b3$$kFZJ
000825273 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131816$$aForschungszentrum Jülich$$b4$$kFZJ
000825273 9131_ $$0G:(DE-HGF)POF3-573$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vNeuroimaging$$x0
000825273 9141_ $$y2016
000825273 920__ $$lyes
000825273 9201_ $$0I:(DE-Juel1)INM-5-20090406$$kINM-5$$lNuklearchemie$$x0
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