%0 Journal Article
%A Zischler, Johannes
%A Krapf, Philipp
%A Richarz, Raphael
%A Zlatopolskiy, Boris D.
%A Neumaier, Bernd
%T Automated synthesis of 4-[$^{18}$F]fluoroanisole, [$^{18}$F]DAA1106 and 4-[$^{18}$F]FPhe using Cu-mediated radiofluorination under “minimalist” conditions
%J Applied radiation and isotopes
%V 115
%@ 0969-8043
%C Amsterdam [u.a.]
%I Elsevier Science
%M FZJ-2016-07767
%P 133 - 137
%D 2016
%X The application of the “minimalist” approach to Cu-mediated radiofluorination allows the efficient preparation of 18F-labeled arenes regardless of their electronic properties. The implementation of this methodology on a commercially available synthesis module (hotboxthree, Scintomics, Germany) enabled the automated production of 4-[18F]fluoroanisole as well as the clinically relevant PET-tracers, 4-[18F]FPhe and [18F]DAA1106, in radiochemical yields of 41–61% and radiochemical purities of >95% within 30–60 min. These results demonstrated the high efficacy and versatility of the developed method that will open up opportunities for a broad application of Cu-mediated radiofluorination in PET-chemistry.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000382594900022
%R 10.1016/j.apradiso.2016.04.030
%U https://juser.fz-juelich.de/record/825303