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000825303 1001_ $$0P:(DE-Juel1)166483$$aZischler, Johannes$$b0$$ufzj
000825303 245__ $$aAutomated synthesis of 4-[$^{18}$F]fluoroanisole, [$^{18}$F]DAA1106 and 4-[$^{18}$F]FPhe using Cu-mediated radiofluorination under “minimalist” conditions
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000825303 520__ $$aThe application of the “minimalist” approach to Cu-mediated radiofluorination allows the efficient preparation of 18F-labeled arenes regardless of their electronic properties. The implementation of this methodology on a commercially available synthesis module (hotboxthree, Scintomics, Germany) enabled the automated production of 4-[18F]fluoroanisole as well as the clinically relevant PET-tracers, 4-[18F]FPhe and [18F]DAA1106, in radiochemical yields of 41–61% and radiochemical purities of >95% within 30–60 min. These results demonstrated the high efficacy and versatility of the developed method that will open up opportunities for a broad application of Cu-mediated radiofluorination in PET-chemistry.
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000825303 7001_ $$0P:(DE-Juel1)169356$$aKrapf, Philipp$$b1$$ufzj
000825303 7001_ $$0P:(DE-Juel1)169321$$aRicharz, Raphael$$b2$$ufzj
000825303 7001_ $$0P:(DE-HGF)0$$aZlatopolskiy, Boris D.$$b3
000825303 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b4$$eCorresponding author$$ufzj
000825303 773__ $$0PERI:(DE-600)1499873-7$$a10.1016/j.apradiso.2016.04.030$$gVol. 115, p. 133 - 137$$p133 - 137$$tApplied radiation and isotopes$$v115$$x0969-8043$$y2016
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