TY  - JOUR
AU  - Zischler, Johannes
AU  - Krapf, Philipp
AU  - Richarz, Raphael
AU  - Zlatopolskiy, Boris D.
AU  - Neumaier, Bernd
TI  - Automated synthesis of 4-[$^{18}$F]fluoroanisole, [$^{18}$F]DAA1106 and 4-[$^{18}$F]FPhe using Cu-mediated radiofluorination under “minimalist” conditions
JO  - Applied radiation and isotopes
VL  - 115
SN  - 0969-8043
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2016-07767
SP  - 133 - 137
PY  - 2016
AB  - The application of the “minimalist” approach to Cu-mediated radiofluorination allows the efficient preparation of 18F-labeled arenes regardless of their electronic properties. The implementation of this methodology on a commercially available synthesis module (hotboxthree, Scintomics, Germany) enabled the automated production of 4-[18F]fluoroanisole as well as the clinically relevant PET-tracers, 4-[18F]FPhe and [18F]DAA1106, in radiochemical yields of 41–61% and radiochemical purities of >95% within 30–60 min. These results demonstrated the high efficacy and versatility of the developed method that will open up opportunities for a broad application of Cu-mediated radiofluorination in PET-chemistry.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000382594900022
DO  - DOI:10.1016/j.apradiso.2016.04.030
UR  - https://juser.fz-juelich.de/record/825303
ER  -