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| Hauptseite > Publikationsdatenbank > Automated synthesis of 4-[$^{18}$F]fluoroanisole, [$^{18}$F]DAA1106 and 4-[$^{18}$F]FPhe using Cu-mediated radiofluorination under “minimalist” conditions > print |
| Hauptseite > Publikationsdatenbank > Automated synthesis of 4-[$^{18}$F]fluoroanisole, [$^{18}$F]DAA1106 and 4-[$^{18}$F]FPhe using Cu-mediated radiofluorination under “minimalist” conditions > print |
| 001 | 825303 | ||
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| 100 | 1 | _ | |a Zischler, Johannes |0 P:(DE-Juel1)166483 |b 0 |u fzj |
| 245 | _ | _ | |a Automated synthesis of 4-[$^{18}$F]fluoroanisole, [$^{18}$F]DAA1106 and 4-[$^{18}$F]FPhe using Cu-mediated radiofluorination under “minimalist” conditions |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2016 |b Elsevier Science |
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| 520 | _ | _ | |a The application of the “minimalist” approach to Cu-mediated radiofluorination allows the efficient preparation of 18F-labeled arenes regardless of their electronic properties. The implementation of this methodology on a commercially available synthesis module (hotboxthree, Scintomics, Germany) enabled the automated production of 4-[18F]fluoroanisole as well as the clinically relevant PET-tracers, 4-[18F]FPhe and [18F]DAA1106, in radiochemical yields of 41–61% and radiochemical purities of >95% within 30–60 min. These results demonstrated the high efficacy and versatility of the developed method that will open up opportunities for a broad application of Cu-mediated radiofluorination in PET-chemistry. |
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| 773 | _ | _ | |a 10.1016/j.apradiso.2016.04.030 |g Vol. 115, p. 133 - 137 |0 PERI:(DE-600)1499873-7 |p 133 - 137 |t Applied radiation and isotopes |v 115 |y 2016 |x 0969-8043 |
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