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000825309 1001_ $$0P:(DE-Juel1)162382$$aDronse, Julian$$b0$$eCorresponding author$$ufzj
000825309 245__ $$aIn vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer’s Disease
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000825309 520__ $$aThe clinical heterogeneity of Alzheimer’s disease is not reflected in the rather diffuse cortical deposition of amyloid-β. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer’s disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-β deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer’s disease.
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000825309 7001_ $$0P:(DE-HGF)0$$aFliessbach, Klaus$$b1
000825309 7001_ $$0P:(DE-Juel1)166265$$aBischof, Gérard N.$$b2$$ufzj
000825309 7001_ $$0P:(DE-Juel1)156372$$avon Reutern, Boris$$b3
000825309 7001_ $$0P:(DE-HGF)0$$aFaber, Jennifer$$b4
000825309 7001_ $$0P:(DE-HGF)0$$aHammes, Jochen$$b5
000825309 7001_ $$0P:(DE-HGF)0$$aKuhnert, Georg$$b6
000825309 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b7$$ufzj
000825309 7001_ $$0P:(DE-HGF)0$$aOnur, Oezguer A.$$b8
000825309 7001_ $$0P:(DE-Juel1)131730$$aKukolja, Juraj$$b9$$ufzj
000825309 7001_ $$0P:(DE-Juel1)169110$$avan Eimeren, Thilo$$b10$$ufzj
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000825309 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b12$$ufzj
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000825309 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-160316$$gVol. 55, no. 2, p. 465 - 471$$n2$$p465 - 471$$tJournal of Alzheimer's disease$$v55$$x1875-8908$$y2017
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