TY  - JOUR
AU  - Dronse, Julian
AU  - Fliessbach, Klaus
AU  - Bischof, Gérard N.
AU  - von Reutern, Boris
AU  - Faber, Jennifer
AU  - Hammes, Jochen
AU  - Kuhnert, Georg
AU  - Neumaier, Bernd
AU  - Onur, Oezguer A.
AU  - Kukolja, Juraj
AU  - van Eimeren, Thilo
AU  - Jessen, Frank
AU  - Fink, Gereon R.
AU  - Klockgether, Thomas
AU  - Drzezga, Alexander
TI  - In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer’s Disease
JO  - Journal of Alzheimer's disease
VL  - 55
IS  - 2
SN  - 1875-8908
CY  - Amsterdam
PB  - IOS Press
M1  - FZJ-2016-07773
SP  - 465 - 471
PY  - 2017
AB  - The clinical heterogeneity of Alzheimer’s disease is not reflected in the rather diffuse cortical deposition of amyloid-β. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer’s disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-β deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer’s disease.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000389695700003
C6  - pmid:27802224
DO  - DOI:10.3233/JAD-160316
UR  - https://juser.fz-juelich.de/record/825309
ER  -