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@ARTICLE{Reim:825465,
      author       = {Reim, Tina and Balfanz, Sabine and Baumann, A. and Blenau,
                      Wolfgang and Thamm, Markus and Scheiner, Ricarda},
      title        = {{A}m{TAR}2: {F}unctional characterization of a honeybee
                      tyramine receptor stimulating adenylyl cyclase activity},
      journal      = {Insect biochemistry and molecular biology},
      volume       = {80},
      issn         = {0965-1748},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2016-07928},
      pages        = {91 - 100},
      year         = {2017},
      abstract     = {The biogenic monoamines norepinephrine and epinephrine
                      regulate important physiological functions in vertebrates.
                      Insects such as honeybees do not synthesize these
                      neuroactive substances. Instead, they employ octopamine and
                      tyramine for comparable physiological functions. These
                      biogenic amines activate specific guanine nucleotide-binding
                      (G) protein-coupled receptors (GPCRs).Based on
                      pharmacological data obtained on heterologously expressed
                      receptors, α- and β-adrenergic-like octopamine receptors
                      are better activated by octopamine than by tyramine.
                      Conversely, GPCRs forming the type 1 tyramine receptor clade
                      (synonymous to octopamine/tyramine receptors) are better
                      activated by tyramine than by octopamine. More recently,
                      receptors were characterized which are almost exclusively
                      activated by tyramine, thus forming an independent type 2
                      tyramine receptor clade. Functionally, type 1 tyramine
                      receptors inhibit adenylyl cyclase activity, leading to a
                      decrease in intracellular cAMP concentration ([cAMP]i). Type
                      2 tyramine receptors can mediate Ca2+ signals or both Ca2+
                      signals and effects on [cAMP]i. We here provide evidence
                      that the honeybee tyramine receptor 2 (AmTAR2), when
                      heterologously expressed in flpTM cells, exclusively causes
                      an increase in [cAMP]i. The receptor displays a pronounced
                      preference for tyramine over octopamine. Its activity can be
                      blocked by a series of established antagonists, of which
                      mianserin and yohimbine are most efficient.The functional
                      characterization of two tyramine receptors from the
                      honeybee, AmTAR1 (previously named AmTYR1) and AmTAR2, which
                      respond to tyramine by changing cAMP levels in opposite
                      direction, is an important step towards understanding the
                      actions of tyramine in honeybee behavior and physiology,
                      particularly in comparison to the effects of octopamine.},
      cin          = {ICS-4},
      ddc          = {590},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000392557800010},
      doi          = {10.1016/j.ibmb.2016.12.004},
      url          = {https://juser.fz-juelich.de/record/825465},
}