guest ::
| Home > Publications database > AmTAR2: Functional characterization of a honeybee tyramine receptor stimulating adenylyl cyclase activity > print |
| Home > Publications database > AmTAR2: Functional characterization of a honeybee tyramine receptor stimulating adenylyl cyclase activity > print |
| 001 | 825465 | ||
| 005 | 20210129225330.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ibmb.2016.12.004 |2 doi |
| 024 | 7 | _ | |a 0965-1748 |2 ISSN |
| 024 | 7 | _ | |a 1879-0240 |2 ISSN |
| 024 | 7 | _ | |a WOS:000392557800010 |2 WOS |
| 037 | _ | _ | |a FZJ-2016-07928 |
| 082 | _ | _ | |a 590 |
| 100 | 1 | _ | |a Reim, Tina |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a AmTAR2: Functional characterization of a honeybee tyramine receptor stimulating adenylyl cyclase activity |
| 260 | _ | _ | |a Amsterdam |c 2017 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1482501190_29337 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The biogenic monoamines norepinephrine and epinephrine regulate important physiological functions in vertebrates. Insects such as honeybees do not synthesize these neuroactive substances. Instead, they employ octopamine and tyramine for comparable physiological functions. These biogenic amines activate specific guanine nucleotide-binding (G) protein-coupled receptors (GPCRs).Based on pharmacological data obtained on heterologously expressed receptors, α- and β-adrenergic-like octopamine receptors are better activated by octopamine than by tyramine. Conversely, GPCRs forming the type 1 tyramine receptor clade (synonymous to octopamine/tyramine receptors) are better activated by tyramine than by octopamine. More recently, receptors were characterized which are almost exclusively activated by tyramine, thus forming an independent type 2 tyramine receptor clade. Functionally, type 1 tyramine receptors inhibit adenylyl cyclase activity, leading to a decrease in intracellular cAMP concentration ([cAMP]i). Type 2 tyramine receptors can mediate Ca2+ signals or both Ca2+ signals and effects on [cAMP]i. We here provide evidence that the honeybee tyramine receptor 2 (AmTAR2), when heterologously expressed in flpTM cells, exclusively causes an increase in [cAMP]i. The receptor displays a pronounced preference for tyramine over octopamine. Its activity can be blocked by a series of established antagonists, of which mianserin and yohimbine are most efficient.The functional characterization of two tyramine receptors from the honeybee, AmTAR1 (previously named AmTYR1) and AmTAR2, which respond to tyramine by changing cAMP levels in opposite direction, is an important step towards understanding the actions of tyramine in honeybee behavior and physiology, particularly in comparison to the effects of octopamine. |
| 536 | _ | _ | |a 552 - Engineering Cell Function (POF3-552) |0 G:(DE-HGF)POF3-552 |c POF3-552 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef |
| 700 | 1 | _ | |a Balfanz, Sabine |0 P:(DE-Juel1)131909 |b 1 |
| 700 | 1 | _ | |a Baumann, A. |0 P:(DE-Juel1)131911 |b 2 |
| 700 | 1 | _ | |a Blenau, Wolfgang |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Thamm, Markus |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Scheiner, Ricarda |0 P:(DE-HGF)0 |b 5 |e Corresponding author |
| 773 | _ | _ | |a 10.1016/j.ibmb.2016.12.004 |g Vol. 80, p. 91 - 100 |0 PERI:(DE-600)1483248-3 |p 91 - 100 |t Insect biochemistry and molecular biology |v 80 |y 2017 |x 0965-1748 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/825465/files/1-s2.0-S096517481630203X-main.pdf |y Restricted |
| 856 | 4 | _ | |x icon |u https://juser.fz-juelich.de/record/825465/files/1-s2.0-S096517481630203X-main.gif?subformat=icon |y Restricted |
| 856 | 4 | _ | |x icon-1440 |u https://juser.fz-juelich.de/record/825465/files/1-s2.0-S096517481630203X-main.jpg?subformat=icon-1440 |y Restricted |
| 856 | 4 | _ | |x icon-180 |u https://juser.fz-juelich.de/record/825465/files/1-s2.0-S096517481630203X-main.jpg?subformat=icon-180 |y Restricted |
| 856 | 4 | _ | |x icon-640 |u https://juser.fz-juelich.de/record/825465/files/1-s2.0-S096517481630203X-main.jpg?subformat=icon-640 |y Restricted |
| 856 | 4 | _ | |x pdfa |u https://juser.fz-juelich.de/record/825465/files/1-s2.0-S096517481630203X-main.pdf?subformat=pdfa |y Restricted |
| 909 | C | O | |o oai:juser.fz-juelich.de:825465 |p VDB |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)131909 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 2 |6 P:(DE-Juel1)131911 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 3 |6 P:(DE-HGF)0 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences |1 G:(DE-HGF)POF3-550 |0 G:(DE-HGF)POF3-552 |2 G:(DE-HGF)POF3-500 |v Engineering Cell Function |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a No Authors Fulltext |0 StatID:(DE-HGF)0550 |2 StatID |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b INSECT BIOCHEM MOLEC : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Juel1)ICS-4-20110106 |k ICS-4 |l Zelluläre Biophysik |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-4-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-1-20200312 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|