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@ARTICLE{Stegmayr:825817,
      author       = {Stegmayr, Carina and Bandelow, Ulrike and Oliveira, Dennis
                      and Lohmann, Philipp and Willuweit, Antje and Filss,
                      Christian and Galldiks, Norbert and Lübke, Joachim H. R.
                      and Shah, N. J. and Ermert, Johannes and Langen, Karl-Josef},
      title        = {{I}nfluence of blood-brain barrier permeability on
                      {O}-(2-$^{18}${F}-fluoroethyl)-{L}-tyrosine uptake in rat
                      gliomas},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {44},
      number       = {3},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2017-00119},
      pages        = {408–416},
      year         = {2017},
      abstract     = {PurposeO-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) is an
                      established tracer for the diagnosis of brain tumors with
                      PET. This study investigates the influence of blood-brain
                      barrier (BBB) permeability on 18F-FET uptake in two rat
                      glioma models and one human xenograft model.MethodsF98
                      glioma, 9L gliosarcoma or human U87 glioblastoma cells were
                      implanted into the striatum of 56 Fischer or RNU rats.
                      Thereafter, animals were divided into a control group and a
                      group receiving injections of the glucocorticoid
                      dexamethasone (Dex). After 12-13 days of tumor growth
                      animals received injection of Evans blue dye (EBD) to
                      visualize BBB disturbance and underwent 18F-FET PET followed
                      by autoradiography. Time activity curves, standardized
                      uptake values (SUV) and Tumor-to-brain ratios (TBR) of
                      18F-FET uptake [18-61 min post injection (p.i.)] were
                      evaluated using a volume-of-Interest (VOI) analysis. BBB
                      disturbance was quantitatively evaluated by EBD
                      fluorescence. The membrane gaps of blood vessel endothelial
                      tight junctions were measured using electron microscopy to
                      visualize ultrastructural BBB alterations in one untreated
                      and one Dex treated F98 glioma. Data were analyzed by
                      two-way ANOVAs.ResultsIn Dex treated animals EBD
                      extravasation was significantly reduced in 9L
                      (P < 0.001) and U87 (P = 0.008) models and showed a
                      trend in F98 models (P = 0.053). In contrast, no
                      significant differences of 18F-FET uptake were observed
                      between Dex treated animals and control group except a
                      decrease of the TBR in the 9L tumor model in PET
                      (P < 0.01). Ultrastructural evaluation of tumor blood
                      vessel endothelia revealed significant reduction of the
                      cleft diameter between endothelial cells after Dex treatment
                      in F98 model (P = 0.010).ConclusionDespite a
                      considerable reduction of BBB permeability in rat gliomas
                      after Dex treatment, no relevant changes of 18F-FET uptake
                      were noted in this experimental study. Thus, 18F-FET uptake
                      in gliomas appears to be widely independent of the
                      permeability of the BBB.},
      cin          = {INM-2 / INM-3 / INM-4 / JARA-BRAIN / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-3-20090406 /
                      I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$ /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000394985100008},
      pubmed       = {pmid:27613541},
      doi          = {10.1007/s00259-016-3508-0},
      url          = {https://juser.fz-juelich.de/record/825817},
}