% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ceccon:825818,
      author       = {Ceccon, Garry and Lohmann, Philipp and Stoffels, Gabriele
                      and Judov, Natalie and Filss, Christian and Rapp, Marion and
                      Bauer, Elena and Hamisch, Christina and Ruge, Maximilian I.
                      and Kocher, Martin and Kuchelmeister, Klaus and Sellhaus,
                      Bernd and Sabel, Michael and Fink, Gereon R. and Shah, Nadim
                      J. and Langen, Karl-Josef and Galldiks, Norbert},
      title        = {{D}ynamic {O} -(2-$^{18}$ {F}-fluoroethyl)-{L}-tyrosine
                      positron emission tomography differentiates brain metastasis
                      recurrence from radiation injury after radiotherapy},
      journal      = {Neuro-Oncology},
      volume       = {19},
      number       = {2},
      issn         = {1523-5866},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2017-00120},
      pages        = {281-288},
      year         = {2017},
      abstract     = {BackgroundThe aim of this study was to investigate the
                      potential of dynamic O-(2-[18F]fluoroethyl)-L-tyrosine
                      (18F-FET) PET for differentiating local recurrent brain
                      metastasis from radiation injury after radiotherapy since
                      contrast-enhanced MRI often remains
                      inconclusive.MethodsSixty-two patients (mean age, 55 ± 11
                      y) with single or multiple contrast-enhancing brain lesions
                      (n = 76) on MRI after radiotherapy of brain metastases
                      (predominantly stereotactic radiosurgery) were investigated
                      with dynamic 18F-FET PET. Maximum and mean tumor-to-brain
                      ratios (TBRmax, TBRmean) of 18F-FET uptake were determined
                      (20–40 min postinjection) as well as tracer uptake
                      kinetics (ie, time-to-peak and slope of time-activity
                      curves). Diagnoses were confirmed histologically $(34\%;$ 26
                      lesions in 25 patients) or by clinical follow-up $(66\%;$ 50
                      lesions in 37 patients). Diagnostic accuracies of PET
                      parameters for the correct identification of recurrent brain
                      metastasis were evaluated by
                      receiver-operating-characteristic analyses or the chi-square
                      test.ResultsTBRs were significantly higher in recurrent
                      metastases (n = 36) than in radiation injuries (n = 40)
                      (TBRmax 3.3 ± 1.0 vs 2.2 ± 0.4, P < .001; TBRmean 2.2 ±
                      0.4 vs 1.7 ± 0.3, P < .001). The highest accuracy $(88\%)$
                      for diagnosing local recurrent metastasis could be obtained
                      with TBRs in combination with the slope of time-activity
                      curves (P < .001).ConclusionsThe results of this study
                      confirm previous preliminary observations that the combined
                      evaluation of the TBRs of 18F-FET uptake and the slope of
                      time-activity curves can differentiate local brain
                      metastasis recurrence from radiation-induced changes with
                      high accuracy. 18F-FET PET may thus contribute significantly
                      to the management of patients with brain metastases.},
      cin          = {INM-3 / INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000397280500015},
      pubmed       = {pmid:27471107},
      doi          = {10.1093/neuonc/now149},
      url          = {https://juser.fz-juelich.de/record/825818},
}