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| 024 | 7 | _ | |a 10.1007/s00330-016-4638-2 |2 doi |
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| 037 | _ | _ | |a FZJ-2017-00126 |
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| 100 | 1 | _ | |a Lohmann, Philipp |0 P:(DE-Juel1)145110 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Radiation injury vs. recurrent brain metastasis: combining textural feature radiomics analysis and standard parameters may increase $^{18}$F-FET PET accuracy without dynamic scans |
| 260 | _ | _ | |a Berlin |c 2017 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1497878258_30052 |2 PUB:(DE-HGF) |
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| 520 | _ | _ | |a ObjectivesWe investigated the potential of textural feature analysis of O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET to differentiate radiation injury from brain metastasis recurrence.MethodsForty-seven patients with contrast-enhancing brain lesions (n = 54) on MRI after radiotherapy of brain metastases underwent dynamic 18F-FET PET. Tumour-to-brain ratios (TBRs) of 18F-FET uptake and 62 textural parameters were determined on summed images 20-40 min post-injection. Tracer uptake kinetics, i.e., time-to-peak (TTP) and patterns of time-activity curves (TAC) were evaluated on dynamic PET data from 0-50 min post-injection. Diagnostic accuracy of investigated parameters and combinations thereof to discriminate between brain metastasis recurrence and radiation injury was compared.ResultsDiagnostic accuracy increased from 81 % for TBRmean alone to 85 % when combined with the textural parameter Coarseness or Short-zone emphasis. The accuracy of TBRmax alone was 83 % and increased to 85 % after combination with the textural parameters Coarseness, Short-zone emphasis, or Correlation. Analysis of TACs resulted in an accuracy of 70 % for kinetic pattern alone and increased to 83 % when combined with TBRmax.ConclusionsTextural feature analysis in combination with TBRs may have the potential to increase diagnostic accuracy for discrimination between brain metastasis recurrence and radiation injury, without the need for dynamic 18F-FET PET scans. |
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| 700 | 1 | _ | |a Stoffels, Gabriele |0 P:(DE-Juel1)131627 |b 1 |
| 700 | 1 | _ | |a Ceccon, Garry |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Rapp, Marion |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Sabel, Michael |0 P:(DE-Juel1)165921 |b 4 |
| 700 | 1 | _ | |a Filss, Christian |0 P:(DE-Juel1)141877 |b 5 |
| 700 | 1 | _ | |a Kamp, Marcel A. |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Stegmayr, Carina |0 P:(DE-Juel1)156479 |b 7 |
| 700 | 1 | _ | |a Neumaier, Bernd |0 P:(DE-Juel1)166419 |b 8 |
| 700 | 1 | _ | |a Shah, Nadim J. |0 P:(DE-Juel1)131794 |b 9 |
| 700 | 1 | _ | |a Langen, Karl-Josef |0 P:(DE-Juel1)131777 |b 10 |
| 700 | 1 | _ | |a Galldiks, Norbert |0 P:(DE-Juel1)143792 |b 11 |
| 773 | _ | _ | |a 10.1007/s00330-016-4638-2 |0 PERI:(DE-600)1472718-3 |n 7 |p 2916–2927 |t European radiology |v 27 |y 2017 |x 1432-1084 |
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