%0 Journal Article
%A Bischof, Gérard N.
%A Jessen, Frank
%A Fliessbach, Klaus
%A Dronse, Julian
%A Hammes, Jochen
%A Neumaier, Bernd
%A Onur, Oezguer
%A Fink, Gereon R.
%A Kukolja, Juraj
%A Drzezga, Alexander
%A van Eimeren, Thilo
%T Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.
%J Annals of Clinical and Translational Neurology
%V 3
%N 12
%@ 2328-9503
%C Chichester [u.a.]
%I Wiley
%M FZJ-2017-00190
%P 934 - 939
%D 2016
%X In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV-1451) and beta-amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000390566700004
%$ pmid:28097205
%R 10.1002/acn3.339
%U https://juser.fz-juelich.de/record/825911