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000825911 1001_ $$0P:(DE-Juel1)166265$$aBischof, Gérard N.$$b0$$eCorresponding author
000825911 245__ $$aImpact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.
000825911 260__ $$aChichester [u.a.]$$bWiley$$c2016
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000825911 520__ $$aIn a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV-1451) and beta-amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease.
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000825911 7001_ $$0P:(DE-HGF)0$$aJessen, Frank$$b1
000825911 7001_ $$0P:(DE-HGF)0$$aFliessbach, Klaus$$b2
000825911 7001_ $$0P:(DE-Juel1)162382$$aDronse, Julian$$b3
000825911 7001_ $$0P:(DE-HGF)0$$aHammes, Jochen$$b4
000825911 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b5
000825911 7001_ $$0P:(DE-HGF)0$$aOnur, Oezguer$$b6
000825911 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b7
000825911 7001_ $$0P:(DE-Juel1)131730$$aKukolja, Juraj$$b8
000825911 7001_ $$0P:(DE-HGF)0$$aDrzezga, Alexander$$b9
000825911 7001_ $$0P:(DE-Juel1)169110$$avan Eimeren, Thilo$$b10
000825911 773__ $$0PERI:(DE-600)2740696-9$$a10.1002/acn3.339$$gVol. 3, no. 12, p. 934 - 939$$n12$$p934 - 939$$tAnnals of Clinical and Translational Neurology$$v3$$x2328-9503$$y2016
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