TY  - JOUR
AU  - Bischof, Gérard N.
AU  - Jessen, Frank
AU  - Fliessbach, Klaus
AU  - Dronse, Julian
AU  - Hammes, Jochen
AU  - Neumaier, Bernd
AU  - Onur, Oezguer
AU  - Fink, Gereon R.
AU  - Kukolja, Juraj
AU  - Drzezga, Alexander
AU  - van Eimeren, Thilo
TI  - Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.
JO  - Annals of Clinical and Translational Neurology
VL  - 3
IS  - 12
SN  - 2328-9503
CY  - Chichester [u.a.]
PB  - Wiley
M1  - FZJ-2017-00190
SP  - 934 - 939
PY  - 2016
AB  - In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV-1451) and beta-amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000390566700004
C6  - pmid:28097205
DO  - DOI:10.1002/acn3.339
UR  - https://juser.fz-juelich.de/record/825911
ER  -