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@ARTICLE{Bischof:825911,
      author       = {Bischof, Gérard N. and Jessen, Frank and Fliessbach, Klaus
                      and Dronse, Julian and Hammes, Jochen and Neumaier, Bernd
                      and Onur, Oezguer and Fink, Gereon R. and Kukolja, Juraj and
                      Drzezga, Alexander and van Eimeren, Thilo},
      title        = {{I}mpact of tau and amyloid burden on glucose metabolism in
                      {A}lzheimer's disease.},
      journal      = {Annals of Clinical and Translational Neurology},
      volume       = {3},
      number       = {12},
      issn         = {2328-9503},
      address      = {Chichester [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2017-00190},
      pages        = {934 - 939},
      year         = {2016},
      abstract     = {In a multimodal PET imaging approach, we determined the
                      differential contribution of neurofibrillary tangles
                      (measured with [18F]AV-1451) and beta-amyloid burden
                      (measured with [11C]PiB) on degree of neurodegeneration
                      (i.e., glucose metabolism measured with [18F]FDG-PET) in
                      patients with Alzheimer's disease. Across brain regions, we
                      observed an interactive effect of beta-amyloid burden and
                      tau deposition on glucose metabolism which was most
                      pronounced in the parietal lobe. Elevated beta-amyloid
                      burden was associated with a stronger influence of tau
                      accumulation on glucose metabolism. Our data provide the
                      first in vivo insights into the differential contribution of
                      Aβ and tau to neurodegeneration in Alzheimer's disease.},
      cin          = {INM-3 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000390566700004},
      pubmed       = {pmid:28097205},
      doi          = {10.1002/acn3.339},
      url          = {https://juser.fz-juelich.de/record/825911},
}