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001     825911
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024 7 _ |a 10.1002/acn3.339
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100 1 _ |a Bischof, Gérard N.
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245 _ _ |a Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.
260 _ _ |a Chichester [u.a.]
|c 2016
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520 _ _ |a In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV-1451) and beta-amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease.
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700 1 _ |a Jessen, Frank
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700 1 _ |a Fliessbach, Klaus
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700 1 _ |a Dronse, Julian
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700 1 _ |a Hammes, Jochen
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700 1 _ |a Neumaier, Bernd
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700 1 _ |a Onur, Oezguer
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700 1 _ |a Fink, Gereon R.
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700 1 _ |a Kukolja, Juraj
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700 1 _ |a Drzezga, Alexander
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700 1 _ |a van Eimeren, Thilo
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773 _ _ |a 10.1002/acn3.339
|g Vol. 3, no. 12, p. 934 - 939
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|t Annals of Clinical and Translational Neurology
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