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@ARTICLE{Kireev:825954,
      author       = {Kireev, Dmitry and Zadorozhnyi, Ihor and Qiu, Tianyu and
                      Sarik, Dario and Brings, Fabian and Wu, Tianru and Seyock,
                      Silke and Maybeck, Vanessa and Lottner, Martin and Blaschke,
                      Benno and Garrido, Jose and Xie, Xiaoming and Vitusevich,
                      Svetlana and Wolfrum, Bernhard and Offenhausser, Andreas},
      title        = {{G}raphene field effect transistors for in vitro and ex
                      vivo recordings},
      journal      = {IEEE transactions on nanotechnology},
      volume       = {16},
      number       = {1},
      issn         = {1941-0085},
      address      = {New York, NY},
      publisher    = {IEEE},
      reportid     = {FZJ-2017-00226},
      pages        = {140 - 147},
      year         = {2017},
      abstract     = {Recording extracellular potentials from electrogenic cells
                      (especially neurons) is the hallmark destination of modern
                      bioelectronics. While fabrication of flexible and
                      biocompatible in vivo devices via silicon technology is
                      complicated and time-consuming, graphene field-effect
                      transistors (GFETs), instead, can easily be fabricated on
                      flexible and biocompatible substrates. In this work, we
                      compare GFETs fabricated on rigid (SiO2 /Si and sapphire)
                      and flexible (polyimide) substrates. The GFETs, fabricated
                      on the polyimide, exhibit extremely large transconductance
                      values, up to 11 mS·V–1, and mobility over 1750 cm2
                      ·V–1·s–1. In vitro recordings from cardiomyocyte-like
                      cell culture are performed by GFETs on a rigid transparent
                      substrate (sapphire). Via multichannel measurement, we are
                      able to record and analyze both: difference in action
                      potentials as well as their spatial propagation over the
                      chip. Furthermore, the controllably flexible
                      polyimide-on-steel (PIonS) substrates are able to ex vivo
                      record electrical signals from primary embryonic rat heart
                      tissue. Considering the flexibility of PIonS chips, together
                      with the excellent sensitivity, we open up a new road into
                      graphene-based in vivo biosensing.},
      cin          = {ICS-8},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000393808000019},
      doi          = {10.1109/TNANO.2016.2639028},
      url          = {https://juser.fz-juelich.de/record/825954},
}