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@ARTICLE{Direk:826053,
      author       = {Direk, Nese and Williams, Stephanie and Smith, Jennifer A.
                      and Ripke, Stephan and Air, Tracy and Amare, Azmeraw T. and
                      Amin, Najaf and Baune, Bernhard T. and Bennett, David A. and
                      Blackwood, Douglas H. R. and Boomsma, Dorret and Breen,
                      Gerome and Buttenschøn, Henriette N. and Byrne, Enda M. and
                      Børglum, Anders D. and Castelao, Enrique and Cichon, Sven
                      and Clarke, Toni-Kim and Cornelis, Marilyn C. and
                      Dannlowski, Udo and De Jager, Philip L. and Demirkan, Ayse
                      and Domenici, Enrico and van Duijn, Cornelia M. and Dunn,
                      Erin C. and Eriksson, Johan G. and Esko, Tonu and Faul,
                      Jessica D. and Ferrucci, Luigi and Fornage, Myriam and de
                      Geus, Eco and Gill, Michael and Gordon, Scott D. and Grabe,
                      Hans Jörgen and van Grootheest, Gerard and Hamilton, Steven
                      P. and Hartman, Catharina A. and Heath, Andrew C. and Hek,
                      Karin and Hofman, Albert and Homuth, Georg and Horn, Carsten
                      and Jan Hottenga, Jouke and Kardia, Sharon L. R. and
                      Kloiber, Stefan and Koenen, Karestan and Kutalik, Zoltán
                      and Ladwig, Karl-Heinz and Lahti, Jari and Levinson, Douglas
                      F. and Lewis, Cathryn M. and Lewis, Glyn and Li, Qingqin S.
                      and Llewellyn, David J. and Lucae, Susanne and Lunetta,
                      Kathryn L. and MacIntyre, Donald J. and Madden, Pamela and
                      Martin, Nicholas G. and McIntosh, Andrew M. and Metspalu,
                      Andres and Milaneschi, Yuri and Montgomery, Grant W. and
                      Mors, Ole and Mosley, Thomas H. and Murabito, Joanne M. and
                      Müller-Myhsok, Bertram and Nöthen, Markus M. and Nyholt,
                      Dale R. and O’Donovan, Michael C. and Penninx, Brenda W.
                      and Pergadia, Michele L. and Perlis, Roy and Potash, James
                      B. and Preisig, Martin and Purcell, Shaun M. and Quiroz,
                      Jorge A. and Räikkönen, Katri and Rice, John P. and
                      Rietschel, Marcella and Rivera, Margarita and Schulze,
                      Thomas G. and Shi, Jianxin and Shyn, Stanley and Sinnamon,
                      Grant C. and Smit, Johannes H. and Smoller, Jordan W. and
                      Snieder, Harold and Tanaka, Toshiko and Tansey, Katherine E.
                      and Teumer, Alexander and Uher, Rudolf and Umbricht, Daniel
                      and Van der Auwera, Sandra and Ware, Erin B. and Weir, David
                      R. and Weissman, Myrna M. and Willemsen, Gonneke and Yang,
                      Jingyun and Zhao, Wei and Tiemeier, Henning and Sullivan,
                      Patrick F.},
      title        = {{A}n {A}nalysis of {T}wo {G}enome-wide {A}ssociation
                      {M}eta-analyses {I}dentifies a {N}ew {L}ocus for {B}road
                      {D}epression {P}henotype},
      journal      = {Biological psychiatry},
      volume       = {82},
      number       = {5},
      issn         = {0006-3223},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2017-00322},
      pages        = {322-329},
      year         = {2017},
      abstract     = {BackgroundThe genetics of depression has been explored in
                      genome-wide association studies that focused on either major
                      depressive disorder or depressive symptoms with mostly
                      negative findings. A broad depression phenotype including
                      both phenotypes has not been tested previously using a
                      genome-wide association approach. We aimed to identify
                      genetic polymorphisms significantly associated with a broad
                      phenotype from depressive symptoms to major depressive
                      disorder.MethodsWe analyzed two prior studies of 70,017
                      participants of European ancestry from general and clinical
                      populations in the discovery stage. We performed a
                      replication meta-analysis of 28,328 participants. Single
                      nucleotide polymorphism (SNP)-based heritability and genetic
                      correlations were calculated using linkage disequilibrium
                      score regression. Discovery and replication analyses were
                      performed using a p-value-based meta-analysis. Lifetime
                      major depressive disorder and depressive symptom scores were
                      used as the outcome measures.ResultsThe SNP-based
                      heritability of major depressive disorder was 0.21 (SE =
                      0.02), the SNP-based heritability of depressive symptoms was
                      0.04 (SE = 0.01), and their genetic correlation was 1.001
                      (SE = 0.2). We found one genome-wide significant locus
                      related to the broad depression phenotype (rs9825823,
                      chromosome 3: 61,082,153, p = 8.2 × 10–9) located in an
                      intron of the FHIT gene. We replicated this SNP in
                      independent samples (p = .02) and the overall meta-analysis
                      of the discovery and replication cohorts (1.0 ×
                      10–9).ConclusionsThis large study identified a new locus
                      for depression. Our results support a continuum between
                      depressive symptoms and major depressive disorder. A
                      phenotypically more inclusive approach may help to achieve
                      the large sample sizes needed to detect susceptibility loci
                      for depression.},
      cin          = {INM-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / HBP - Human
                      Brain Project (284941)},
      pid          = {G:(DE-HGF)POF3-571 / G:(EU-Grant)284941},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000406938900010},
      pubmed       = {pmid:28049566},
      doi          = {10.1016/j.biopsych.2016.11.013},
      url          = {https://juser.fz-juelich.de/record/826053},
}