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@ARTICLE{Seyock:826223,
      author       = {Seyock, Silke and Maybeck, Vanessa and Scorsone, Emmanuel
                      and Rousseau, Lionel and Hébert, Clément and Lissorgues,
                      Gaëlle and Bergonzo, Philippe and Offenhäusser, Andreas},
      title        = {{I}nterfacing neurons on carbon nanotubes covered with
                      diamond},
      journal      = {RSC Advances},
      volume       = {7},
      number       = {1},
      issn         = {2046-2069},
      address      = {London},
      publisher    = {RSC Publishing},
      reportid     = {FZJ-2017-00469},
      pages        = {153 - 160},
      year         = {2017},
      abstract     = {A recently discovered material, carbon nanotubes covered
                      with diamond (DCNTs) was tested for its suitability in
                      bioelectronics applications. Diamond shows advantages for
                      bioelectronics applications (wide electro chemical window
                      and bioinertness). This study investigates the effect of
                      electrode surface shape (flat or three dimensional) on cell
                      growth and behavior. For comparison, flat nanocrystalline
                      diamond substrates were used. Primary embryonic neurons were
                      grown on top of the structures and neither incorporated the
                      structures nor did they grow in between the single
                      structures. The interface was closely examined using focused
                      ion beam (FIB) and scanning electron microscopy. Of special
                      interest was the interface between cell and substrate. $5\%$
                      to $25\%$ of the cell membrane adhered to the substrate,
                      which fits the theoretical estimated value. While
                      investigating the conformity of the neurons, it could be
                      observed that the cell membrane attaches to different
                      heights of the tips of the 3D structure. However, the aspect
                      ratio of the structures had no effect on the cell viability.
                      These results let us assume that not more than $25\%$ of
                      cell attachment is needed for the survival of a functional
                      neuronal cell.},
      cin          = {ICS-8},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000393741900023},
      doi          = {10.1039/C6RA20207A},
      url          = {https://juser.fz-juelich.de/record/826223},
}