TY  - JOUR
AU  - Galldiks, Norbert
AU  - Law, Ian
AU  - Pope, Whitney B.
AU  - Arbizu, Javier
AU  - Langen, Karl-Josef
TI  - The use of amino acid PET and conventional MRI for monitoring of brain tumor therapy
JO  - NeuroImage: Clinical
VL  - 13
SN  - 2213-1582
CY  - [Amsterdam u.a.]
PB  - Elsevier
M1  - FZJ-2017-00705
SP  - 386 - 394
PY  - 2017
AB  - Routine diagnostics and treatment monitoring of brain tumors is usually based on contrast-enhanced MRI. However, the capacity of conventional MRI to differentiate tumor tissue from posttherapeutic effects following neurosurgical resection, chemoradiation, alkylating chemotherapy, radiosurgery, and/or immunotherapy may be limited. Metabolic imaging using PET can provide relevant additional information on tumor metabolism, which allows for more accurate diagnostics especially in clinically equivocal situations. This review article focuses predominantly on the amino acid PET tracers 11C-methyl-l-methionine (MET), O-(2-[18F]fluoroethyl)-l-tyrosine (FET) and 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (FDOPA) and summarizes investigations regarding monitoring of brain tumor therapy.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000401413700045
C6  - pmid:28116231
DO  - DOI:10.1016/j.nicl.2016.12.020
UR  - https://juser.fz-juelich.de/record/826480
ER  -