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@ARTICLE{Lange:826796,
      author       = {Lange, Catharina and Suppa, Per and Mäurer, Anja and
                      Ritter, Kerstin and Pietrzyk, Uwe and Steinhagen-Thiessen,
                      Elisabeth and Fiebach, Jochen B. and Spies, Lothar and
                      Buchert, Ralph},
      title        = {{M}ental speed is associated with the shape irregularity of
                      white matter {MRI} hyperintensity load},
      journal      = {Brain imaging and behavior},
      volume       = {11},
      issn         = {1931-7565},
      address      = {New York, NY [u.a.]},
      publisher    = {Springer},
      reportid     = {FZJ-2017-01013},
      pages        = {1720–1730},
      year         = {2017},
      abstract     = {Brain MRI white matter hyperintensities (WMHs) are common
                      in elderly subjects. Their impact on cognition, however,
                      appears highly variable. Complementing conventional scoring
                      of WMH load (volume and location) by quantitative
                      characterization of the shape irregularity of WMHs might
                      improve the understanding of the relationship between WMH
                      load and cognitive performance. Here we propose the
                      “confluency sum score” (COSU) as a marker of the total
                      shape irregularity of WMHs in the brain. The study included
                      two independent patient samples: 87 cognitively impaired
                      geriatric inpatients from a prospective neuroimaging study
                      (iDSS) and 198 subjects from the National Alzheimer’s
                      Coordinating Center (NACC) database (132 with, 66 w/o
                      cognitive impairment). After automatic segmentation and
                      clustering of the WMHs on FLAIR (LST toolbox, SPM8), the
                      confluency of the i-th contiguous WMH cluster was computed
                      as confluencyi = [1/(36π)∙surfacei 3/volumei 2]1/3–1.
                      The COSU was obtained by summing the confluency over all WMH
                      clusters. COSU was tested for correlation with CERAD-plus
                      subscores. Correlation analysis was restricted to subjects
                      with at least moderate WMH load (≥ 13.5 ml; iDSS / NACC: n
                      = 52 / 80). In the iDSS sample, among the 12 CERAD-plus
                      subtests the trail making test A (TMT-A) was most strongly
                      correlated with the COSU (Spearman rho = −0.345, p =
                      0.027). TMT-A performance was not associated with total WMH
                      volume (rho = 0.147, p = 0.358). This finding was confirmed
                      in the NACC sample (rho = −0.261, p = 0.023 versus rho =
                      −0.040, p = 0.732). Cognitive performance in specific
                      domains including mental speed and fluid abilities seems to
                      be more strongly associated with the shape irregularity of
                      white matter MRI hyperintensities than with their volume.},
      cin          = {INM-4 / JARA-BRAIN},
      ddc          = {150},
      cid          = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27796731},
      UT           = {WOS:000416555800014},
      doi          = {10.1007/s11682-016-9647-x},
      url          = {https://juser.fz-juelich.de/record/826796},
}