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| Home > Publications database > Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation > print |
| 001 | 826950 | ||
| 005 | 20210129225727.0 | ||
| 024 | 7 | _ | |a 10.1021/acsnano.6b02627 |2 doi |
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| 100 | 1 | _ | |a Streich, Carmen |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation |
| 260 | _ | _ | |a Washington, DC |c 2016 |b Soc. |
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| 520 | _ | _ | |a Therapeutically active small molecules represent promising nonimmunogenic alternatives to antibodies for specifically targeting disease-relevant receptors. However, a potential drawback compared to antibody–antigen interactions may be the lower affinity of small molecules toward receptors. Here, we overcome this low-affinity problem by coating the surface of nanoparticles (NPs) with multiple ligands. Specifically, we explored the use of gold and platinum nanoparticles to increase the binding affinity of Aβ-specific small molecules to inhibit Aβ peptide aggregation into fibrils in vitro. The interactions of bare NPs, free ligands, and NP-bound ligands with Aβ are comprehensively studied via physicochemical methods (spectroscopy, microscopy, immunologic tests) and cell assays. Reduction of thioflavin T fluorescence, as an indicator for β-sheet content, and inhibition of cellular Aβ excretion are even more effective with NP-bound ligands than with the free ligands. The results from this study may have implications in the development of therapeutics for treating Alzheimer’s disease. |
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| 700 | 1 | _ | |a Niemeyer, Felix Carlsson |0 P:(DE-HGF)0 |b 6 |
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