TY  - JOUR
AU  - Madadi Asl, Mojtaba
AU  - Valizadeh, Alireza
AU  - Tass, Peter A.
TI  - Dendritic and Axonal Propagation Delays Determine Emergent Structures of Neuronal Networks with Plastic Synapses
JO  - Scientific reports
VL  - 7
SN  - 2045-2322
M1  - FZJ-2017-01407
SP  - 39682
PY  - 2017
AB  - Spike-timing-dependent plasticity (STDP) modifies synaptic strengths based on the relative timing of pre- and postsynaptic spikes. The temporal order of spikes turned out to be crucial. We here take into account how propagation delays, composed of dendritic and axonal delay times, may affect the temporal order of spikes. In a minimal setting, characterized by neglecting dendritic and axonal propagation delays, STDP eliminates bidirectional connections between two coupled neurons and turns them into unidirectional connections. In this paper, however, we show that depending on the dendritic and axonal propagation delays, the temporal order of spikes at the synapses can be different from those in the cell bodies and, consequently, qualitatively different connectivity patterns emerge. In particular, we show that for a system of two coupled oscillatory neurons, bidirectional synapses can be preserved and potentiated. Intriguingly, this finding also translates to large networks of type-II phase oscillators and, hence, crucially impacts on the overall hierarchical connectivity patterns of oscillatory neuronal networks.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000391028600001
C6  - pmid:28045109
DO  - DOI:10.1038/srep39682
UR  - https://juser.fz-juelich.de/record/827209
ER  -