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@ARTICLE{Luchini:827565,
      author       = {Luchini, Alessandra and Gerelli, Yuri and Fragneto,
                      Giovanna and Nylander, Tommy and Pálsson, Gunnar K and
                      Appavou, Marie-Sousai and Paduano, Luigi},
      title        = {{N}eutron {R}eflectometry reveals the interaction between
                      functionalized {SPION}s and the surface of lipid bilayers},
      journal      = {Colloids and surfaces / B},
      volume       = {151},
      issn         = {0927-7765},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2017-01685},
      pages        = {76 - 87},
      year         = {2017},
      abstract     = {The safe application of nanotechnology devices in
                      biomedicine requires fundamental understanding on how they
                      interact with and affect the different components of
                      biological systems. In this respect, the cellular membrane,
                      the cell envelope, certainly represents an important target
                      or barrier for nanosystems. Here we report on the
                      interaction between functionalized SuperParamagnetic Iron
                      Oxide Nanoparticles (SPIONs), promising contrast agents for
                      Magnetic Resonance Imaging (MRI), and lipid bilayers that
                      mimic the plasma membrane. Neutron Reflectometry, supported
                      by Quartz Crystal Microbalance with Dissipation monitoring
                      (QCM-D) experiments, was used to characterize this
                      interaction by varying both SPION coating and lipid bilayer
                      composition. In particular, the interaction of two different
                      SPIONs, functionalized with a cationic surfactant and a
                      zwitterionic phospholipid, and lipid bilayers, containing
                      different amount of cholesterol, were compared. The obtained
                      results were further validated by Dynamic Light Scattering
                      (DLS) measurements and Cryogenic Transmission Electron
                      Microscopy (Cryo-TEM) images. None of the investigated
                      functionalized SPIONs were found to disrupt the lipid
                      membrane. However, in all case we observed the attachment of
                      the functionalized SPIONs onto the surface of the bilayers,
                      which was affected by the bilayer rigidity, i.e. the
                      cholesterol concentration.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)TEM-MLZ-20151210},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000394475400010},
      doi          = {10.1016/j.colsurfb.2016.12.005},
      url          = {https://juser.fz-juelich.de/record/827565},
}