TY  - JOUR
AU  - Barz, Claudia
AU  - Bessaih, Thomas
AU  - Abel, Ted
AU  - Feldmeyer, Dirk
AU  - Contreras, Diego
TI  - Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1
JO  - Brain structure & function
VL  - 221
IS  - 9
SN  - 1863-2661
CY  - Berlin
PB  - Springer
M1  - FZJ-2017-01724
SP  - 4383 - 4398
PY  - 2016
AB  - To reveal the neuronal underpinnings of sensory processing deficits in patients with schizophrenia, previous studies have investigated brain activity in response to sustained sensory stimulation at various frequencies. This paradigm evoked neural activity at the stimulation frequency and harmonics thereof. During visual and auditory stimulation that elicited enhanced or ‘resonant’ responses in healthy controls, patients with schizophrenia displayed reduced activity. The present study sought to elucidate the cellular basis of disease-related deficits in sensory resonance properties using mice heterozygous for the schizophrenia susceptibility gene Neuregulin 1 (NRG1). We applied repetitive whisker stimulation at 1–15 Hz, a range relevant to whisking behavior in mice, and measured cellular activity in the primary somatosensory cortex. At frequencies where control mice displayed enhancements in measures of response magnitude and precision, NRG1 (+/−) mutants showed reductions. Our results demonstrate for the first time a link between a mutation of a schizophrenia risk gene and altered neuronal resonance properties in sensory cortex.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000387657200006
C6  - pmid:26721794
DO  - DOI:10.1007/s00429-015-1169-6
UR  - https://juser.fz-juelich.de/record/827605
ER  -