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@ARTICLE{Barz:827605,
      author       = {Barz, Claudia and Bessaih, Thomas and Abel, Ted and
                      Feldmeyer, Dirk and Contreras, Diego},
      title        = {{A}ltered resonance properties of somatosensory responses
                      in mice deficient for the schizophrenia risk gene
                      {N}euregulin 1},
      journal      = {Brain structure $\&$ function},
      volume       = {221},
      number       = {9},
      issn         = {1863-2661},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2017-01724},
      pages        = {4383 - 4398},
      year         = {2016},
      abstract     = {To reveal the neuronal underpinnings of sensory processing
                      deficits in patients with schizophrenia, previous studies
                      have investigated brain activity in response to sustained
                      sensory stimulation at various frequencies. This paradigm
                      evoked neural activity at the stimulation frequency and
                      harmonics thereof. During visual and auditory stimulation
                      that elicited enhanced or ‘resonant’ responses in
                      healthy controls, patients with schizophrenia displayed
                      reduced activity. The present study sought to elucidate the
                      cellular basis of disease-related deficits in sensory
                      resonance properties using mice heterozygous for the
                      schizophrenia susceptibility gene Neuregulin 1 (NRG1). We
                      applied repetitive whisker stimulation at 1–15 Hz, a range
                      relevant to whisking behavior in mice, and measured cellular
                      activity in the primary somatosensory cortex. At frequencies
                      where control mice displayed enhancements in measures of
                      response magnitude and precision, NRG1 (+/−) mutants
                      showed reductions. Our results demonstrate for the first
                      time a link between a mutation of a schizophrenia risk gene
                      and altered neuronal resonance properties in sensory
                      cortex.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000387657200006},
      pubmed       = {pmid:26721794},
      doi          = {10.1007/s00429-015-1169-6},
      url          = {https://juser.fz-juelich.de/record/827605},
}