guest ::
| Home > Publications database > Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1 > print |
| Home > Publications database > Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1 > print |
| 001 | 827605 | ||
| 005 | 20210129225859.0 | ||
| 024 | 7 | _ | |a 10.1007/s00429-015-1169-6 |2 doi |
| 024 | 7 | _ | |a 0340-2061 |2 ISSN |
| 024 | 7 | _ | |a 1432-0568 |2 ISSN |
| 024 | 7 | _ | |a 1863-2653 |2 ISSN |
| 024 | 7 | _ | |a 1863-2661 |2 ISSN |
| 024 | 7 | _ | |a WOS:000387657200006 |2 WOS |
| 024 | 7 | _ | |a altmetric:4942916 |2 altmetric |
| 024 | 7 | _ | |a pmid:26721794 |2 pmid |
| 037 | _ | _ | |a FZJ-2017-01724 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Barz, Claudia |0 P:(DE-Juel1)138803 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1 |
| 260 | _ | _ | |a Berlin |c 2016 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1486709783_5792 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a To reveal the neuronal underpinnings of sensory processing deficits in patients with schizophrenia, previous studies have investigated brain activity in response to sustained sensory stimulation at various frequencies. This paradigm evoked neural activity at the stimulation frequency and harmonics thereof. During visual and auditory stimulation that elicited enhanced or ‘resonant’ responses in healthy controls, patients with schizophrenia displayed reduced activity. The present study sought to elucidate the cellular basis of disease-related deficits in sensory resonance properties using mice heterozygous for the schizophrenia susceptibility gene Neuregulin 1 (NRG1). We applied repetitive whisker stimulation at 1–15 Hz, a range relevant to whisking behavior in mice, and measured cellular activity in the primary somatosensory cortex. At frequencies where control mice displayed enhancements in measures of response magnitude and precision, NRG1 (+/−) mutants showed reductions. Our results demonstrate for the first time a link between a mutation of a schizophrenia risk gene and altered neuronal resonance properties in sensory cortex. |
| 536 | _ | _ | |a 571 - Connectivity and Activity (POF3-571) |0 G:(DE-HGF)POF3-571 |c POF3-571 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef |
| 700 | 1 | _ | |a Bessaih, Thomas |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Abel, Ted |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Feldmeyer, Dirk |0 P:(DE-Juel1)131680 |b 3 |u fzj |
| 700 | 1 | _ | |a Contreras, Diego |0 P:(DE-HGF)0 |b 4 |
| 773 | _ | _ | |a 10.1007/s00429-015-1169-6 |g Vol. 221, no. 9, p. 4383 - 4398 |0 PERI:(DE-600)2303775-1 |n 9 |p 4383 - 4398 |t Brain structure & function |v 221 |y 2016 |x 1863-2661 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/827605/files/art_10.1007_s00429-015-1169-6.pdf |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/827605/files/art_10.1007_s00429-015-1169-6.gif?subformat=icon |x icon |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/827605/files/art_10.1007_s00429-015-1169-6.jpg?subformat=icon-1440 |x icon-1440 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/827605/files/art_10.1007_s00429-015-1169-6.jpg?subformat=icon-180 |x icon-180 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/827605/files/art_10.1007_s00429-015-1169-6.jpg?subformat=icon-640 |x icon-640 |y Restricted |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/827605/files/art_10.1007_s00429-015-1169-6.pdf?subformat=pdfa |x pdfa |y Restricted |
| 909 | C | O | |o oai:juser.fz-juelich.de:827605 |p VDB |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-Juel1)138803 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 3 |6 P:(DE-Juel1)131680 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Decoding the Human Brain |1 G:(DE-HGF)POF3-570 |0 G:(DE-HGF)POF3-571 |2 G:(DE-HGF)POF3-500 |v Connectivity and Activity |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2016 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b BRAIN STRUCT FUNCT : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b BRAIN STRUCT FUNCT : 2015 |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-2-20090406 |k INM-2 |l Molekulare Organisation des Gehirns |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)INM-2-20090406 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|