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@ARTICLE{Barz:827606,
      author       = {Barz, Claudia and Bessaih, Thomas and Abel, Ted and
                      Feldmeyer, Dirk and Contreras, Diego},
      title        = {{S}ensory encoding in {N}euregulin 1 mutants},
      journal      = {Brain structure $\&$ function},
      volume       = {221},
      number       = {2},
      issn         = {1863-2661},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2017-01725},
      pages        = {1067 - 1081},
      year         = {2016},
      abstract     = {Schizophrenic patients show altered sensory perception as
                      well as changes in electrical and magnetic brain responses
                      to sustained, frequency-modulated sensory stimulation. Both
                      the amplitude and temporal precision of the neural responses
                      differ in patients as compared to control subjects, and
                      these changes are most pronounced for stimulation at gamma
                      frequencies (20–40 Hz). In addition, patients display
                      enhanced spontaneous gamma oscillations, which has been
                      interpreted as ‘neural noise’ that may interfere with
                      normal stimulus processing. To investigate
                      electrophysiological markers of aberrant sensory processing
                      in a model of schizophrenia, we recorded neuronal activity
                      in primary somatosensory cortex of mice heterozygous for the
                      schizophrenia susceptibility gene Neuregulin 1. Sensory
                      responses to sustained 20–70 Hz whisker stimulation were
                      analyzed with respect to firing rates, spike precision
                      (phase locking) and gamma oscillations, and compared to
                      baseline conditions. The mutants displayed elevated
                      spontaneous firing rates, a reduced gain in sensory-evoked
                      spiking and gamma activity, and reduced spike precision of
                      20–40 Hz responses. These findings present the first in
                      vivo evidence of the linkage between a genetic marker and
                      altered stimulus encoding, thus suggesting a novel
                      electrophysiological endophenotype of schizophrenia.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000371380100020},
      pubmed       = {pmid:25515311},
      doi          = {10.1007/s00429-014-0955-x},
      url          = {https://juser.fz-juelich.de/record/827606},
}