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@ARTICLE{Oberwelland:827727,
      author       = {Oberwelland, E. and Schilbach, L. and Barisic, I. and
                      Krall, S. C. and Vogeley, K. and Fink, G. R. and
                      Herpertz-Dahlmann, B. and Konrad, K. and Schulte-Rüther,
                      M.},
      title        = {{Y}oung adolescents with autism show abnormal joint
                      attention network: {A} gaze contingent f{MRI} study},
      journal      = {NeuroImage: Clinical},
      volume       = {14},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2017-01835},
      pages        = {112 - 121},
      year         = {2017},
      abstract     = {Behavioral research has revealed deficits in the
                      development of joint attention (JA) as one of the earliest
                      signs of autism. While the neural basis of JA has been
                      studied predominantly in adults, we recently demonstrated a
                      protracted development of the brain networks supporting JA
                      in typically developing children and adolescents. The
                      present eye-tracking/fMRI study now extends these findings
                      to adolescents with autism. Our results show that in
                      adolescents with autism JA is subserved by abnormal
                      activation patterns in brain areas related to social
                      cognition abnormalities which are at the core of ASD
                      including the STS and TPJ, despite behavioral maturation
                      with no behavioral differences. Furthermore, in the autism
                      group we observed increased neural activity in a network of
                      social and emotional processing areas during interactions
                      with their mother. Moreover, data indicated that less
                      severely affected individuals with autism showed higher
                      frontal activation associated with self-initiated
                      interactions. Taken together, this study provides first-time
                      data of JA in children/adolescents with autism incorporating
                      the interactive character of JA, its reciprocity and
                      motivational aspects. The observed functional differences in
                      adolescents ASD suggest that persistent developmental
                      differences in the neural processes underlying JA contribute
                      to social interaction difficulties in ASD.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000405984300012},
      pubmed       = {pmid:28180069},
      doi          = {10.1016/j.nicl.2017.01.006},
      url          = {https://juser.fz-juelich.de/record/827727},
}