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000827735 1001_ $$0P:(DE-HGF)0$$aKeller, Andreas J$$b0$$eCorresponding author
000827735 245__ $$aStimulus relevance modulates contrast adaptation in visual cortex
000827735 260__ $$aCambridge$$beLife Sciences Publications$$c2017
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000827735 520__ $$aA general principle of sensory processing is that neurons adapt to sustained stimuli by reducing their response over time. Most of our knowledge on adaptation in single cells is based on experiments in anesthetized animals. How responses adapt in awake animals, when stimuli may be behaviorally relevant or not, remains unclear. Here we show that contrast adaptation in mouse primary visual cortex depends on the behavioral relevance of the stimulus. Cells that adapted to contrast under anesthesia maintained or even increased their activity in awake naïve mice. When engaged in a visually guided task, contrast adaptation re-occurred for stimuli that were irrelevant for solving the task. However, contrast adaptation was reversed when stimuli acquired behavioral relevance. Regulation of cortical adaptation by task demand may allow dynamic control of sensory-evoked signal flow in the neocortex.
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000827735 7001_ $$0P:(DE-HGF)0$$aHoulton, Rachael$$b1
000827735 7001_ $$0P:(DE-Juel1)168305$$aKampa, Björn$$b2
000827735 7001_ $$0P:(DE-HGF)0$$aLesica, Nicholas A$$b3
000827735 7001_ $$0P:(DE-HGF)0$$aMrsic-Flogel, Thomas D$$b4
000827735 7001_ $$0P:(DE-HGF)0$$aKeller, Georg B$$b5
000827735 7001_ $$0P:(DE-HGF)0$$aHelmchen, Fritjof$$b6
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