TY  - JOUR
AU  - Keller, Andreas J
AU  - Houlton, Rachael
AU  - Kampa, Björn
AU  - Lesica, Nicholas A
AU  - Mrsic-Flogel, Thomas D
AU  - Keller, Georg B
AU  - Helmchen, Fritjof
TI  - Stimulus relevance modulates contrast adaptation in visual cortex
JO  - eLife
VL  - 6
SN  - 2050-084X
CY  - Cambridge
PB  - eLife Sciences Publications
M1  - FZJ-2017-01841
SP  - e21589
PY  - 2017
AB  - A general principle of sensory processing is that neurons adapt to sustained stimuli by reducing their response over time. Most of our knowledge on adaptation in single cells is based on experiments in anesthetized animals. How responses adapt in awake animals, when stimuli may be behaviorally relevant or not, remains unclear. Here we show that contrast adaptation in mouse primary visual cortex depends on the behavioral relevance of the stimulus. Cells that adapted to contrast under anesthesia maintained or even increased their activity in awake naïve mice. When engaged in a visually guided task, contrast adaptation re-occurred for stimuli that were irrelevant for solving the task. However, contrast adaptation was reversed when stimuli acquired behavioral relevance. Regulation of cortical adaptation by task demand may allow dynamic control of sensory-evoked signal flow in the neocortex.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000394261300001
C6  - pmid:28130922
DO  - DOI:10.7554/eLife.21589
UR  - https://juser.fz-juelich.de/record/827735
ER  -