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@ARTICLE{Keller:827735,
      author       = {Keller, Andreas J and Houlton, Rachael and Kampa, Björn
                      and Lesica, Nicholas A and Mrsic-Flogel, Thomas D and
                      Keller, Georg B and Helmchen, Fritjof},
      title        = {{S}timulus relevance modulates contrast adaptation in
                      visual cortex},
      journal      = {eLife},
      volume       = {6},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {FZJ-2017-01841},
      pages        = {e21589},
      year         = {2017},
      abstract     = {A general principle of sensory processing is that neurons
                      adapt to sustained stimuli by reducing their response over
                      time. Most of our knowledge on adaptation in single cells is
                      based on experiments in anesthetized animals. How responses
                      adapt in awake animals, when stimuli may be behaviorally
                      relevant or not, remains unclear. Here we show that contrast
                      adaptation in mouse primary visual cortex depends on the
                      behavioral relevance of the stimulus. Cells that adapted to
                      contrast under anesthesia maintained or even increased their
                      activity in awake naïve mice. When engaged in a visually
                      guided task, contrast adaptation re-occurred for stimuli
                      that were irrelevant for solving the task. However, contrast
                      adaptation was reversed when stimuli acquired behavioral
                      relevance. Regulation of cortical adaptation by task demand
                      may allow dynamic control of sensory-evoked signal flow in
                      the neocortex.},
      cin          = {INM-2},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000394261300001},
      pubmed       = {pmid:28130922},
      doi          = {10.7554/eLife.21589},
      url          = {https://juser.fz-juelich.de/record/827735},
}