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@ARTICLE{Keller:827735,
author = {Keller, Andreas J and Houlton, Rachael and Kampa, Björn
and Lesica, Nicholas A and Mrsic-Flogel, Thomas D and
Keller, Georg B and Helmchen, Fritjof},
title = {{S}timulus relevance modulates contrast adaptation in
visual cortex},
journal = {eLife},
volume = {6},
issn = {2050-084X},
address = {Cambridge},
publisher = {eLife Sciences Publications},
reportid = {FZJ-2017-01841},
pages = {e21589},
year = {2017},
abstract = {A general principle of sensory processing is that neurons
adapt to sustained stimuli by reducing their response over
time. Most of our knowledge on adaptation in single cells is
based on experiments in anesthetized animals. How responses
adapt in awake animals, when stimuli may be behaviorally
relevant or not, remains unclear. Here we show that contrast
adaptation in mouse primary visual cortex depends on the
behavioral relevance of the stimulus. Cells that adapted to
contrast under anesthesia maintained or even increased their
activity in awake naïve mice. When engaged in a visually
guided task, contrast adaptation re-occurred for stimuli
that were irrelevant for solving the task. However, contrast
adaptation was reversed when stimuli acquired behavioral
relevance. Regulation of cortical adaptation by task demand
may allow dynamic control of sensory-evoked signal flow in
the neocortex.},
cin = {INM-2},
ddc = {500},
cid = {I:(DE-Juel1)INM-2-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000394261300001},
pubmed = {pmid:28130922},
doi = {10.7554/eLife.21589},
url = {https://juser.fz-juelich.de/record/827735},
}