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000827774 0247_ $$2doi$$a10.1038/srep41811
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000827774 1001_ $$0P:(DE-Juel1)131968$$aIshchenko, Andrii$$b0
000827774 245__ $$aNew Insights on Signal Propagation by Sensory Rhodopsin II/Transducer Complex
000827774 260__ $$aLondon$$bNature Publishing Group$$c2017
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000827774 520__ $$aThe complex of two membrane proteins, sensory rhodopsin II (NpSRII) with its cognate transducer (NpHtrII), mediates negative phototaxis in halobacteria N. pharaonis. Upon light activation NpSRII triggers a signal transduction chain homologous to the two-component system in eubacterial chemotaxis. Here we report on crystal structures of the ground and active M-state of the complex in the space group I212121. We demonstrate that the relative orientation of symmetrical parts of the dimer is parallel (“U”-shaped) contrary to the gusset-like (“V”-shaped) form of the previously reported structures of the NpSRII/NpHtrII complex in the space group P21212, although the structures of the monomers taken individually are nearly the same. Computer modeling of the HAMP domain in the obtained “V”- and “U”-shaped structures revealed that only the “U”-shaped conformation allows for tight interactions of the receptor with the HAMP domain. This is in line with existing data and supports biological relevance of the “U” shape in the ground state. We suggest that the “V”-shaped structure may correspond to the active state of the complex and transition from the “U” to the “V”-shape of the receptor-transducer complex can be involved in signal transduction from the receptor to the signaling domain of NpHtrII.
000827774 536__ $$0G:(DE-HGF)POF3-551$$a551 - Functional Macromolecules and Complexes (POF3-551)$$cPOF3-551$$fPOF III$$x0
000827774 7001_ $$0P:(DE-HGF)0$$aRound, E.$$b1
000827774 7001_ $$0P:(DE-Juel1)144613$$aBorshchevskiy, Valentin$$b2
000827774 7001_ $$0P:(DE-HGF)0$$aGrudinin, S.$$b3
000827774 7001_ $$0P:(DE-Juel1)165798$$aGushchin, Ivan$$b4
000827774 7001_ $$0P:(DE-HGF)0$$aKlare, J. P.$$b5
000827774 7001_ $$0P:(DE-HGF)0$$aRemeeva$$b6
000827774 7001_ $$0P:(DE-HGF)0$$aPolovinkin, V.$$b7
000827774 7001_ $$0P:(DE-HGF)0$$aUtrobin, P.$$b8
000827774 7001_ $$0P:(DE-Juel1)131949$$aBalandin, Taras$$b9$$ufzj
000827774 7001_ $$0P:(DE-HGF)0$$aEngelhard, M.$$b10
000827774 7001_ $$0P:(DE-Juel1)131957$$aBüldt, Georg$$b11
000827774 7001_ $$0P:(DE-Juel1)131964$$aGordeliy, Valentin$$b12$$eCorresponding author$$ufzj
000827774 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/srep41811$$p41811$$tScientific reports$$v7$$x2045-2322$$y2017
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