TY  - JOUR
AU  - Richter, Nils
AU  - Michel, Anne
AU  - Onur, Özgür
AU  - Kracht, Lutz
AU  - Dietlein, Markus
AU  - Tittgemeyer, Marc
AU  - Neumaier, Bernd
AU  - Fink, Gereon R.
AU  - Kukolja, Juraj
TI  - White matter lesions and the cholinergic deficit in aging and mild cognitive impairment
JO  - Neurobiology of aging
VL  - 53
SN  - 0197-4580
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2017-01935
SP  - 27 - 35
PY  - 2017
AB  - In Alzheimer's disease (AD), white matter lesions (WMLs) are associated with an increased risk of progression from mild cognitive impairment (MCI) to dementia, while memory deficits have, at least in part, been linked to a cholinergic deficit. We investigated the relationship between WML load assessed with the Scheltens scale, cerebral acetylcholinesterase (AChE) activity measured with [11C]N-methyl-4-piperidyl acetate PET, and neuropsychological performance in 17 patients with MCI due to AD and 18 cognitively normal older participants. Only periventricular, not nonperiventricular, WML load negatively correlated with AChE activity in both groups. Memory performance depended on periventricular and total WML load across groups. Crucially, AChE activity predicted memory function better than WML load, gray matter atrophy, or age. The effects of WML load on memory were fully mediated by AChE activity. Data suggest that the contribution of WML to the dysfunction of the cholinergic system in MCI due to AD depends on WML distribution. Pharmacologic studies are warranted to explore whether this influences the response to cholinergic treatment.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000399501300004
C6  - pmid:28208063
DO  - DOI:10.1016/j.neurobiolaging.2017.01.012
UR  - https://juser.fz-juelich.de/record/827844
ER  -