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@ARTICLE{Richter:827844,
      author       = {Richter, Nils and Michel, Anne and Onur, Özgür and
                      Kracht, Lutz and Dietlein, Markus and Tittgemeyer, Marc and
                      Neumaier, Bernd and Fink, Gereon R. and Kukolja, Juraj},
      title        = {{W}hite matter lesions and the cholinergic deficit in aging
                      and mild cognitive impairment},
      journal      = {Neurobiology of aging},
      volume       = {53},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2017-01935},
      pages        = {27 - 35},
      year         = {2017},
      abstract     = {In Alzheimer's disease (AD), white matter lesions (WMLs)
                      are associated with an increased risk of progression from
                      mild cognitive impairment (MCI) to dementia, while memory
                      deficits have, at least in part, been linked to a
                      cholinergic deficit. We investigated the relationship
                      between WML load assessed with the Scheltens scale, cerebral
                      acetylcholinesterase (AChE) activity measured with
                      [11C]N-methyl-4-piperidyl acetate PET, and
                      neuropsychological performance in 17 patients with MCI due
                      to AD and 18 cognitively normal older participants. Only
                      periventricular, not nonperiventricular, WML load negatively
                      correlated with AChE activity in both groups. Memory
                      performance depended on periventricular and total WML load
                      across groups. Crucially, AChE activity predicted memory
                      function better than WML load, gray matter atrophy, or age.
                      The effects of WML load on memory were fully mediated by
                      AChE activity. Data suggest that the contribution of WML to
                      the dysfunction of the cholinergic system in MCI due to AD
                      depends on WML distribution. Pharmacologic studies are
                      warranted to explore whether this influences the response to
                      cholinergic treatment.},
      cin          = {INM-3 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000399501300004},
      pubmed       = {pmid:28208063},
      doi          = {10.1016/j.neurobiolaging.2017.01.012},
      url          = {https://juser.fz-juelich.de/record/827844},
}