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| 001 | 827951 | ||
| 005 | 20210129225944.0 | ||
| 024 | 7 | _ | |a 10.1039/C6RA27829A |2 doi |
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| 100 | 1 | _ | |a Fasbender, Stefan |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Uptake dynamics of graphene quantum dots into primary human blood cells following in vitro exposure |
| 260 | _ | _ | |a London |c 2017 |b RSC Publishing |
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| 520 | _ | _ | |a Human leukocytes obtained from samples of leukapheresis products of three healthy donors stimulated by granulocyte colony stimulating factor (G-CSF) were exposed to graphene quantum dots. A time- and concentration dependent uptake was observed with a significantly greater uptake into monocytes and granulocytes in comparison to lymphocytes, suggesting a better incorporation ability of cells with phagocytotic properties. The uptake rates also correlate with the cell membrane area. Looking at the different lymphoid subsets a greater uptake was found into CD19+ B-, CD56+ natural killer cells and CD34+ hematopoietic stem cells (HSC) in comparison to CD4+ T- and CD8+ T cells. Independent of the cell type studied, the observed uptake dynamics is consistent with a diffusion-driven process, which allows the determination of cell-specific membrane permeabilities for the graphene quantum dots. The toxicity of the quantum dots is relatively low resulting in a 90% viability of the entire leukocyte population after 36 hours of exposure to GQDs at a concentration of 500 μg ml−1. |
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| 700 | 1 | _ | |a Allani, Sonja |0 P:(DE-HGF)0 |b 1 |
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| 700 | 1 | _ | |a Cadeddu, Ron-Patrick |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Raba, Katharina |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Fischer, Johannes C. |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Bulat, Bekir |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Luysberg, Martina |0 P:(DE-Juel1)130811 |b 7 |
| 700 | 1 | _ | |a Seidel, Claus A. M. |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Heinzel, Thomas |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Haas, Rainer |0 P:(DE-HGF)0 |b 10 |e Corresponding author |
| 773 | _ | _ | |a 10.1039/C6RA27829A |g Vol. 7, no. 20, p. 12208 - 12216 |0 PERI:(DE-600)2623224-8 |n 20 |p 12208 - 12216 |t RSC Advances |v 7 |y 2017 |x 2046-2069 |
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