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@ARTICLE{DaVela:828004,
      author       = {Da Vela, Stefano and Braun, Michal K. and Dörr, Andreas
                      and Greco, Alessandro and Möller, Johannes and Fu, Zhendong
                      and Zhang, Fajun and Schreiber, Frank},
      title        = {{K}inetics of liquid–liquid phase separation in protein
                      solutions exhibiting {LCST} phase behavior studied by
                      time-resolved {USAXS} and {VSANS}},
      journal      = {Soft matter},
      volume       = {12},
      number       = {46},
      issn         = {1744-6848},
      address      = {London},
      publisher    = {Royal Soc. of Chemistry},
      reportid     = {FZJ-2017-02026},
      pages        = {9334 - 9341},
      year         = {2016},
      abstract     = {We study the kinetics of the liquid–liquid phase
                      separation (LLPS) and its arrest in protein solutions
                      exhibiting a lower critical solution temperature (LCST)
                      phase behavior using the combination of ultra-small angle
                      X-ray scattering (USAXS) and very-small angle neutron
                      scattering (VSANS). We employ a previously established model
                      system consisting of bovine serum albumin (BSA) solutions
                      with YCl3. We follow the phase transition from sub-second to
                      104 s upon an off-critical temperature jump. After a
                      temperature jump, the USAXS profiles exhibit a peak that
                      grows in intensity and shifts to lower q values with time.
                      Below 45 °C, the characteristic length scale (ξ) obtained
                      from this scattering peak increases with time with a power
                      of about 1/3 for different sample compositions. This is in
                      good agreement with the theoretical prediction for the
                      intermediate stage of spinodal decomposition where the
                      growth is driven by interface tension. Above 45 °C, ξ
                      follows initially the 1/3 power law growth, then undergoes a
                      significant slowdown, and an arrested state is reached below
                      the denaturation temperature of the protein. This growth
                      kinetics may indicate that the final composition of the
                      protein-rich phase is located close to the high density
                      branch of the LLPS binodal when a kinetically arrested state
                      is reached.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / JCNS-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-2-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS3-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000389322800009},
      doi          = {10.1039/C6SM01837H},
      url          = {https://juser.fz-juelich.de/record/828004},
}