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@ARTICLE{Hinney:828027,
author = {Hinney, A. and Kesselmeier, M. and Jall, S. and Volckmar,
A-L and Föcker, M. and Antel, J. and Perica, Vesna Boraska
and Franklin, Christopher S and Floyd, James A B and
Thornton, Laura M and Huckins, Laura M and Southam, Lorraine
and Rayner, N William and Tachmazidou, Ioanna and Klump,
Kelly L and Treasure, Janet and Lewis, Cathryn M and
Schmidt, Ulrike and Tozzi, Federica and iezebrink, Kirsty
and Hebebrand, Johannes and Gorwood, Philip and Adan, Roger
A H and Kas, Martien J H and Favaro, Angela and
Santonastaso, Paolo and Fernández-Aranda, Fernando and
Gratacos, Monica and Rybakowski, Filip and Dmitrzak-Weglarz,
Monika and Kaprio, Jaakko and Keski-Rahkonen, Anna and
Raevuori-Helkamaa, Anu and Van Furth, Eric F and Slof-Op't
Landt, Margarita C T and Hudson, James I and
Reichborn-Kjennerud, Ted and Knudsen, Gun Peggy S and
Monteleone, Palmiero and Kaplan, Allan S and Karwautz,
Andreas and Hakonarson, Hakon and Berrettini, Wade H and
Guo, Yiran and Li, Dong and Schork, Nicholas J and Komaki,
Gen and Ando, Tetsuya and Inoko, Hidetoshi and Esko, Tõnu
and Fischer, Krista and Männik, Katrin and Metspalu, Andres
and Baker, Jessica H and Cone, Roger D and Dackor, Jennifer
and DeSocio, Janiece E and Hilliard, Christopher E and
O'Toole, Julie K and Pantel, Jacques and Szatkiewicz, Jin P
and Taico, Chrysecolla and Zerwas, Stephanie and Trace, Sara
E and Davis, Oliver S P and Helder, Sietske and Bühren,
Katharina and Burghardt, Roland and de Zwaan, Martina and
Egberts, Karin and Ehrlich, Stefan and Herpertz-Dahlmann,
Beate and Herzog, Wolfgang and Imgart, Hartmut and Scherag,
André and Scherag, Susann and Zipfel, Stephan and Boni,
Claudette and Ramoz, Nicolas and Versini, Audrey and
Brandys, Marek K and Danner, Unna N and de Kove, Carolien
and Hendriks, Judith and Koeleman, Bobby P C and Ophoff,
Roel A and Strengman, Eric and van Elburg, Annemarie A and
Bruson, Alice and Clementi, Maurizio and Degortes, Daniela
and Forzan, Monica and Tenconi, Elena and Docampo, Elisa and
Escaramí, Geòrgia and Jiménez-Murcia, Susana and
Lissowska, Jolanta and Rajewski, Andrzej and
Szeszenia-Dabrowska, Neonila and Slopien, Agnieszka and
Hauser, Joanna and Karhunen, Leila and Meulenbelt, Ingrid
and Slagboom, P Eline and Tortorella, Alfonso and Maj, Mario
and Dedoussis, George and Dikeos, Dimitris and Gonidakis,
Fragiskos and Tziouvas, Konstantinos and Tsitsika, Artemis
and Papezova, Hana and Slachtova, Lenka and Martaskova,
Debora and Kennedy, James L and Levitan, Robert D and
Yilmaz, Zeynep and Huemer, Julia and Koubek, Doris and Merl,
Elisabeth and Wagner, Gudrun and Lichtenstein, Paul and
Breen, Gerome and Cohen-Woods, Sarah and Farmer, Anne and
McGuffin, Peter and Cichon, Sven and Giegling, Ina and
Herms, Stefan and Rujescu, Dan and Schreiber, Stefan and
Wichmann, H-Erich and Dina, Christian and Sladek, Rob and
Gambaro, Giovanni and Soranzo, Nicole and Julia, Antonio and
Marsal, Sara and Rabionet, Raquel and Gaborieau, Valerie and
Dick, Danielle M and Palotie, Aarno and Ripatti, Samuli and
Widén, Elisabeth and Andreassen, Ole A and Espeseth, Thomas
and Lundervold, Astri and Reinvang, Ivar and Steen, Vidar M
and Hellard, Stephanie Le and Mattingsdal, Morten and
Ntalla, Ioanna and Bencko, Vladimir and Foretova, Lenka and
Janout, Vladimir and Navratilova, Marie and Gallinger,
Steven and Pinto, Dalila and Scherer, Stephen W and
Aschauer, Harald and Carlberg, Laura and Schosser, Alexandra
and Alfredsson, Lars and Ding, Bo and Klareskog, Lars and
Padyukov, Leonid and Finan, Chris and Kalsi, Gursharan and
Roberts, Marion and Logan, Darren W and Peltonen, Leena and
Ritchie, Graham R S and Barrett, Jeff C and Estivill, Xavier
and Hinney, Anke and Sullivan, Patrick F and Collier, David
A and Zeggini, Eleftheria and Bulik, Cynthia M and Anderson,
Carl A and Barrett, Jeffrey C and Floyd, James A B and
Franklin, Christopher S and McGinnis, Ralph and Soranzo,
Nicole and Zeggini, Eleftheria and Sambrook, Jennifer and
Stephens, Jonathan and Ouwehand, Willem H and McArdle, Wendy
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Graeme and Bulik, Cynthia M and Collier, David A and Conlon,
Peter J and Dominiczak, Anna and Duncanson, Audrey and Hill,
Adrian and Langford, Cordelia and Lord, Graham and Maxwell,
Alexander P and Morgan, Linda and Peltonen, Leena and
Sandford, Richard N and Sheerin, Neil and Vannberg, Frederik
O and Blackburn, Hannah and Chen, Wei-Min and Edkins, Sarah
and Gillman, Mathew and Gray, Emma and Hunt, Sarah E and
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Guo, Y. and Bergen, A. W. and Kaye, W. and Berrettini, W.
and Hakonarson, H. and Brandt, Harry and Crawford, Steve and
Crow, Scott and Fichter, Manfred M and Halmi, Katherine A
and Johnson, Craig and Kaplan, Allan S and Via, Maria La and
Mitchell, James and Strober, Michael and Rotondo, Alessandro
and Treasure, Janet and Woodside, D Blake and Bulik, Cynthia
M and Keel, Pamela and Klump, Kelly L and Lilenfeld, Lisa
and Thornton, Laura M and Plotnicov, Kathy and Bergen,
Andrew W and Berrettini, Wade and Kaye, Walter and
Magistretti, Pierre and Herpertz-Dahlmann, B. and de Zwaan,
M. and Herzog, W. and Ehrlich, S. and Zipfel, S. and
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Scherag, A. and Müller, T. D. and Hebebrand, J.},
title = {{E}vidence for three genetic loci involved in both anorexia
nervosa risk and variation of body mass indexcoh},
journal = {Molecular psychiatry},
volume = {22},
number = {2},
issn = {1476-5578},
address = {London},
publisher = {Macmillan},
reportid = {FZJ-2017-02041},
pages = {192 - 201},
year = {2017},
abstract = {The maintenance of normal body weight is disrupted in
patients with anorexia nervosa (AN) for prolonged periods of
time. Prior to the onset of AN, premorbid body mass index
(BMI) spans the entire range from underweight to obese.
After recovery, patients have reduced rates of overweight
and obesity. As such, loci involved in body weight
regulation may also be relevant for AN and vice versa. Our
primary analysis comprised a cross-trait analysis of the
1000 single-nucleotide polymorphisms (SNPs) with the lowest
P-values in a genome-wide association meta-analysis (GWAMA)
of AN (GCAN) for evidence of association in the largest
published GWAMA for BMI (GIANT). Subsequently we performed
sex-stratified analyses for these 1000 SNPs. Functional ex
vivo studies on four genes ensued. Lastly, a look-up of
GWAMA-derived BMI-related loci was performed in the AN
GWAMA. We detected significant associations (P-values <5 ×
10−5, Bonferroni-corrected P<0.05) for nine SNP alleles at
three independent loci. Interestingly, all AN susceptibility
alleles were consistently associated with increased BMI.
None of the genes (chr. 10: CTBP2, chr. 19: CCNE1, chr. 2:
CARF and NBEAL1; the latter is a region with high linkage
disequilibrium) nearest to these SNPs has previously been
associated with AN or obesity. Sex-stratified analyses
revealed that the strongest BMI signal originated
predominantly from females (chr. 10 rs1561589; Poverall:
2.47 × 10−06/Pfemales: 3.45 × 10−07/Pmales: 0.043).
Functional ex vivo studies in mice revealed reduced
hypothalamic expression of Ctbp2 and Nbeal1 after fasting.
Hypothalamic expression of Ctbp2 was increased in
diet-induced obese (DIO) mice as compared with age-matched
lean controls. We observed no evidence for associations for
the look-up of BMI-related loci in the AN GWAMA. A
cross-trait analysis of AN and BMI loci revealed variants at
three chromosomal loci with potential joint impact. The
chromosome 10 locus is particularly promising given that the
association with obesity was primarily driven by females. In
addition, the detected altered hypothalamic expression
patterns of Ctbp2 and Nbeal1 as a result of fasting and DIO
implicate these genes in weight regulation.},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571) / HBP SGA1 -
Human Brain Project Specific Grant Agreement 1 (720270)},
pid = {G:(DE-HGF)POF3-571 / G:(EU-Grant)720270},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000394102600007},
pubmed = {pmid:27184124},
doi = {10.1038/mp.2016.71},
url = {https://juser.fz-juelich.de/record/828027},
}
Gast ::