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000828030 245__ $$aInfluence of age and cognitive performance on resting-state brain networks of older adults in a population-based cohort
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000828030 520__ $$aAging leads to global changes in brain structure and cognitive performance, with reorganization of functional brain networks. Importantly, these age-related changes show higher inter-individual variability in older subjects. To particularly address this variability is a challenge for studies on lifetime trajectories from early to late adulthood. The present study therefore had a dedicated focus on late adulthood to characterize the functional connectivity in resting-state networks (RSFC) in relation to age and cognitive performance in 711 older adults (55–85 years) from the 1000BRAINS project. The executive, left and right frontoparietal resting-state (RS) networks showed age-related increases in RSFC. However, older adults did not show changes in RSFC in the default mode network (DMN). Furthermore, lower performance in working memory (WM) was associated with higher RSFC in the left frontoparietal RS network. The results suggest age-related compensatory increases in RSFC which might help to maintain cognitive performance. Nevertheless, the negative correlation between RSFC and WM performance hints at limited cognitive reserve capacity in lower performing older adults. Consequently, the current results provide evidence for a functional reorganization of the brain until late adulthood that might additionally explain parts of the variability of cognitive abilities in older adults.
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000828030 7001_ $$0P:(DE-Juel1)131675$$aCaspers, Svenja$$b1$$eCorresponding author
000828030 7001_ $$0P:(DE-Juel1)131733$$aLux, Silke$$b2
000828030 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b3
000828030 7001_ $$aJütten, Kerstin$$b4
000828030 7001_ $$aLenzen, Stefan$$b5
000828030 7001_ $$aMoebus, Susanne$$b6
000828030 7001_ $$aPundt, Noreen$$b7
000828030 7001_ $$0P:(DE-Juel1)162109$$aReid, Andrew$$b8
000828030 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b9
000828030 7001_ $$aJöckel, Karl-Heinz$$b10
000828030 7001_ $$aErbel, Raimund$$b11
000828030 7001_ $$0P:(DE-Juel1)140234$$aCichon, Sven$$b12
000828030 7001_ $$0P:(DE-HGF)0$$aNöthen, Markus M.$$b13
000828030 7001_ $$0P:(DE-Juel1)131794$$aShah, N. J.$$b14
000828030 7001_ $$0P:(DE-Juel1)131714$$aZilles, Karl$$b15
000828030 7001_ $$0P:(DE-Juel1)131631$$aAmunts, Katrin$$b16
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