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@ARTICLE{Jockwitz:828030,
      author       = {Jockwitz, Christiane and Caspers, Svenja and Lux, Silke and
                      Eickhoff, Simon and Jütten, Kerstin and Lenzen, Stefan and
                      Moebus, Susanne and Pundt, Noreen and Reid, Andrew and
                      Hoffstaedter, Felix and Jöckel, Karl-Heinz and Erbel,
                      Raimund and Cichon, Sven and Nöthen, Markus M. and Shah, N.
                      J. and Zilles, Karl and Amunts, Katrin},
      title        = {{I}nfluence of age and cognitive performance on
                      resting-state brain networks of older adults in a
                      population-based cohort},
      journal      = {Cortex},
      volume       = {89},
      issn         = {0010-9452},
      address      = {Paris},
      publisher    = {Elsevier Masson},
      reportid     = {FZJ-2017-02044},
      pages        = {28 - 44},
      year         = {2017},
      abstract     = {Aging leads to global changes in brain structure and
                      cognitive performance, with reorganization of functional
                      brain networks. Importantly, these age-related changes show
                      higher inter-individual variability in older subjects. To
                      particularly address this variability is a challenge for
                      studies on lifetime trajectories from early to late
                      adulthood. The present study therefore had a dedicated focus
                      on late adulthood to characterize the functional
                      connectivity in resting-state networks (RSFC) in relation to
                      age and cognitive performance in 711 older adults (55–85
                      years) from the 1000BRAINS project. The executive, left and
                      right frontoparietal resting-state (RS) networks showed
                      age-related increases in RSFC. However, older adults did not
                      show changes in RSFC in the default mode network (DMN).
                      Furthermore, lower performance in working memory (WM) was
                      associated with higher RSFC in the left frontoparietal RS
                      network. The results suggest age-related compensatory
                      increases in RSFC which might help to maintain cognitive
                      performance. Nevertheless, the negative correlation between
                      RSFC and WM performance hints at limited cognitive reserve
                      capacity in lower performing older adults. Consequently, the
                      current results provide evidence for a functional
                      reorganization of the brain until late adulthood that might
                      additionally explain parts of the variability of cognitive
                      abilities in older adults.},
      cin          = {INM-1 / INM-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / HBP SGA1 -
                      Human Brain Project Specific Grant Agreement 1 (720270)},
      pid          = {G:(DE-HGF)POF3-571 / G:(EU-Grant)720270},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000399261000003},
      pubmed       = {pmid:28192723},
      doi          = {10.1016/j.cortex.2017.01.008},
      url          = {https://juser.fz-juelich.de/record/828030},
}