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@ARTICLE{Hibar:828031,
author = {Hibar, Derrek P. and Adams, Hieab H. H. and Jahanshad, Neda
and Chauhan, Ganesh and Stein, Jason L. and Hofer, Edith and
Renteria, Miguel E. and Bis, Joshua C. and Arias-Vasquez,
Alejandro and Ikram, M. Kamran and Desrivières, Sylvane and
Vernooij, Meike W. and Abramovic, Lucija and Alhusaini, Saud
and Amin, Najaf and Andersson, Micael and Arfanakis,
Konstantinos and Aribisala, Benjamin S. and Armstrong,
Nicola J. and Athanasiu, Lavinia and Axelsson, Tomas and
Beecham, Ashley H. and Beiser, Alexa and Bernard, Manon and
Blanton, Susan H. and Bohlken, Marc M. and Boks, Marco P.
and Bralten, Janita and Brickman, Adam M. and Carmichael,
Owen and Chakravarty, M. Mallar and Chen, Qiang and Ching,
Christopher R. K. and Chouraki, Vincent and Cuellar-Partida,
Gabriel and Crivello, Fabrice and Den Braber, Anouk and
Doan, Nhat Trung and Ehrlich, Stefan and Giddaluru, Sudheer
and Goldman, Aaron L. and Gottesman, Rebecca F. and Grimm,
Oliver and Griswold, Michael E. and Guadalupe, Tulio and
Gutman, Boris A. and Hass, Johanna and Haukvik, Unn K. and
Hoehn, David and Holmes, Avram J. and Hoogman, Martine and
Janowitz, Deborah and Jia, Tianye and Jørgensen, Kjetil N.
and Karbalai, Nazanin and Kasperaviciute, Dalia and Kim,
Sungeun and Klein, Marieke and Kraemer, Bernd and Lee, Phil
H. and Liewald, David C. M. and Lopez, Lorna M. and Luciano,
Michelle and Macare, Christine and Marquand, Andre F. and
Matarin, Mar and Mather, Karen A. and Mattheisen, Manuel and
McKay, David R. and Milaneschi, Yuri and Muñoz Maniega,
Susana and Nho, Kwangsik and Nugent, Allison C. and Nyquist,
Paul and Loohuis, Loes M. Olde and Oosterlaan, Jaap and
Papmeyer, Martina and Pirpamer, Lukas and Pütz, Benno and
Ramasamy, Adaikalavan and Richards, Jennifer S. and
Risacher, Shannon L. and Roiz-Santiañez, Roberto and
Rommelse, Nanda and Ropele, Stefan and Rose, Emma J. and
Royle, Natalie A. and Rundek, Tatjana and Sämann, Philipp
G. and Saremi, Arvin and Satizabal, Claudia L. and Schmaal,
Lianne and Schork, Andrew J. and Shen, Li and Shin, Jean and
Shumskaya, Elena and Smith, Albert V. and Sprooten, Emma and
Strike, Lachlan T. and Teumer, Alexander and
Tordesillas-Gutierrez, Diana and Toro, Roberto and Trabzuni,
Daniah and Trompet, Stella and Vaidya, Dhananjay and Van der
Grond, Jeroen and Van der Lee, Sven J. and Van der Meer,
Dennis and Van Donkelaar, Marjolein M. J. and Van Eijk,
Kristel R. and Van Erp, Theo G. M. and Van Rooij, Daan and
Walton, Esther and Westlye, Lars T. and Whelan, Christopher
D. and Windham, Beverly G. and Winkler, Anderson M. and
Wittfeld, Katharina and Woldehawariat, Girma and Wolf,
Christiane and Wolfers, Thomas and Yanek, Lisa R. and Yang,
Jingyun and Zijdenbos, Alex and Zwiers, Marcel P. and
Agartz, Ingrid and Almasy, Laura and Ames, David and
Amouyel, Philippe and Andreassen, Ole A. and Arepalli,
Sampath and Assareh, Amelia A. and Barral, Sandra and
Bastin, Mark E. and Becker, Diane M. and Becker, James T.
and Bennett, David A. and Blangero, John and van Bokhoven,
Hans and Boomsma, Dorret I. and Brodaty, Henry and Brouwer,
Rachel M. and Brunner, Han G. and Buckner, Randy L. and
Buitelaar, Jan K. and Bulayeva, Kazima B. and Cahn, Wiepke
and Calhoun, Vince D. and Cannon, Dara M. and Cavalleri,
Gianpiero L. and Cheng, Ching-Yu and Cichon, Sven and
Cookson, Mark R. and Corvin, Aiden and Crespo-Facorro,
Benedicto and Curran, Joanne E. and Czisch, Michael and
Dale, Anders M. and Davies, Gareth E. and De Craen, Anton J.
M. and De Geus, Eco J. C. and De Jager, Philip L. and De
Zubicaray, Greig I. and Deary, Ian J. and Debette,
Stéphanie and DeCarli, Charles and Delanty, Norman and
Depondt, Chantal and DeStefano, Anita and Dillman, Allissa
and Djurovic, Srdjan and Donohoe, Gary and Drevets, Wayne C.
and Duggirala, Ravi and Dyer, Thomas D. and Enzinger,
Christian and Erk, Susanne and Espeseth, Thomas and Fedko,
Iryna O. and Fernández, Guillén and Ferrucci, Luigi and
Fisher, Simon E. and Fleischman, Debra A. and Ford, Ian and
Fornage, Myriam and Foroud, Tatiana M. and Fox, Peter T. and
Francks, Clyde and Fukunaga, Masaki and Gibbs, J. Raphael
and Glahn, David C. and Gollub, Randy L. and Göring, Harald
H. H. and Green, Robert C. and Gruber, Oliver and Gudnason,
Vilmundur and Guelfi, Sebastian and Håberg, Asta K. and
Hansell, Narelle K. and Hardy, John and Hartman, Catharina
A. and Hashimoto, Ryota and Hegenscheid, Katrin and Heinz,
Andreas and Le Hellard, Stephanie and Hernandez, Dena G. and
Heslenfeld, Dirk J. and Ho, Beng-Choon and Hoekstra, Pieter
J. and Hoffmann, Wolfgang and Hofman, Albert and Holsboer,
Florian and Homuth, Georg and Hosten, Norbert and Hottenga,
Jouke-Jan and Huentelman, Matthew and Pol, Hilleke E.
Hulshoff and Ikeda, Masashi and Jack Jr, Clifford R. and
Jenkinson, Mark and Johnson, Robert and Jönsson, Erik G.
and Jukema, J. Wouter and Kahn, René S. and Kanai, Ryota
and Kloszewska, Iwona and Knopman, David S. and Kochunov,
Peter and Kwok, John B. and Lawrie, Stephen M. and
Lemaître, Hervé and Liu, Xinmin and Longo, Dan L. and
Lopez, Oscar L. and Lovestone, Simon and Martinez, Oliver
and Martinot, Jean-Luc and Mattay, Venkata S. and McDonald,
Colm and McIntosh, Andrew M. and McMahon, Francis J. and
McMahon, Katie L. and Mecocci, Patrizia and Melle, Ingrid
and Meyer-Lindenberg, Andreas and Mohnke, Sebastian and
Montgomery, Grant W. and Morris, Derek W. and Mosley, Thomas
H. and Mühleisen, Thomas W. and Müller-Myhsok, Bertram and
Nalls, Michael A. and Nauck, Matthias and Nichols, Thomas E.
and Niessen, Wiro J. and Nöthen, Markus M. and Nyberg, Lars
and Ohi, Kazutaka and Olvera, Rene L. and Ophoff, Roel A.
and Pandolfo, Massimo and Paus, Tomas and Pausova, Zdenka
and Penninx, Brenda W. J. H. and Pike, G. Bruce and Potkin,
Steven G. and Psaty, Bruce M. and Reppermund, Simone and
Rietschel, Marcella and Roffman, Joshua L. and
Romanczuk-Seiferth, Nina and Rotter, Jerome I. and Ryten,
Mina and Sacco, Ralph L. and Sachdev, Perminder S. and
Saykin, Andrew J. and Schmidt, Reinhold and Schmidt, Helena
and Schofield, Peter R. and Sigursson, Sigurdur and Simmons,
Andrew and Singleton, Andrew and Sisodiya, Sanjay M. and
Smith, Colin and Smoller, Jordan W. and Soininen, Hilkka and
Steen, Vidar M. and Stott, David J. and Sussmann, Jessika E.
and Thalamuthu, Anbupalam and Toga, Arthur W. and Traynor,
Bryan J. and Troncoso, Juan and Tsolaki, Magda and Tzourio,
Christophe and Uitterlinden, Andre G. and Hernández, Maria
C. Valdés and Van der Brug, Marcel and van der Lugt, Aad
and van der Wee, Nic J. A. and Van Haren, Neeltje E. M. and
van ’t Ent, Dennis and Van Tol, Marie-Jose and Vardarajan,
Badri N. and Vellas, Bruno and Veltman, Dick J. and Völzke,
Henry and Walter, Henrik and Wardlaw, Joanna M. and Wassink,
Thomas H. and Weale, Michael E. and Weinberger, Daniel R.
and Weiner, Michael W. and Wen, Wei and Westman, Eric and
White, Tonya and Wong, Tien Y. and Wright, Clinton B. and
Zielke, Ronald H. and Zonderman, Alan B. and Martin,
Nicholas G. and Van Duijn, Cornelia M. and Wright, Margaret
J. and Longstreth, W. T. and Schumann, Gunter and Grabe,
Hans J. and Franke, Barbara and Launer, Lenore J. and
Medland, Sarah E. and Seshadri, Sudha and Thompson, Paul M.
and Ikram, M. Arfan},
title = {{N}ovel genetic loci associated with hippocampal volume},
journal = {Nature Communications},
volume = {8},
issn = {2041-1723},
address = {London},
publisher = {Nature Publishing Group},
reportid = {FZJ-2017-02045},
pages = {13624},
year = {2017},
abstract = {The hippocampal formation is a brain structure integrally
involved in episodic memory, spatial navigation, cognition
and stress responsiveness. Structural abnormalities in
hippocampal volume and shape are found in several common
neuropsychiatric disorders. To identify the genetic
underpinnings of hippocampal structure here we perform a
genome-wide association study (GWAS) of 33,536 individuals
and discover six independent loci significantly associated
with hippocampal volume, four of them novel. Of the novel
loci, three lie within genes (ASTN2, DPP4 and MAST4) and one
is found 200 kb upstream of SHH. A hippocampal subfield
analysis shows that a locus within the MSRB3 gene shows
evidence of a localized effect along the dentate gyrus,
subiculum, CA1 and fissure. Further, we show that genetic
variants associated with decreased hippocampal volume are
also associated with increased risk for Alzheimer’s
disease (rg=−0.155). Our findings suggest novel biological
pathways through which human genetic variation influences
hippocampal volume and risk for neuropsychiatric illness.},
cin = {INM-1},
ddc = {500},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000392154900001},
pubmed = {pmid:28098162},
doi = {10.1038/ncomms13624},
url = {https://juser.fz-juelich.de/record/828031},
}
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