%0 Journal Article
%A Giegling, Ina
%A Hosak, Ladislav
%A Mössner, Rainald
%A Serretti, Alessandro
%A Bellivier, Frank
%A Claes, Stephan
%A Collier, David A.
%A Corrales, Alejo
%A DeLisi, Lynn E.
%A Gallo, Carla
%A Gill, Michael
%A Kennedy, James L.
%A Leboyer, Marion
%A Maier, Wolfgang
%A Marquez, Miguel
%A Massat, Isabelle
%A Mors, Ole
%A Muglia, Pierandrea
%A Nöthen, Markus M.
%A Ospina-Duque, Jorge
%A Owen, Michael J.
%A Propping, Peter
%A Shi, YongYong
%A St Clair, David
%A Thibaut, Florence
%A Cichon, Sven
%A Mendlewicz, Julien
%A O'Donovan, Michael C.
%A Rujescu, Dan
%T Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics
%J The world journal of biological psychiatry
%V 18
%N 7
%@ 1814-1412
%C Abingdon
%I Taylor & Francis Group
%M FZJ-2017-02047
%P 492-505
%D 2017
%X AbstractObjectives: Schizophrenia is a severe psychiatric disease affecting about 1% of the general population. The relative contribution of genetic factors has been estimated to be up to 80%. The mode of inheritance is complex, non-Mendelian, and in most cases involving the combined action of large numbers of genes.Methods: This review summarises recent efforts to identify genetic variants associated with schizophrenia detected, e.g., through genome-wide association studies, studies on copy-number variants or next-generation sequencing.Results: A large, new body of evidence on genetics of schizophrenia has accumulated over recent years. Many new robustly associated genetic loci have been detected. Furthermore, there is consensus that at least a dozen microdeletions and microduplications contribute to the disease. Genetic overlap between schizophrenia, other psychiatric disorders, and neurodevelopmental syndromes raised new questions regarding the current classification of psychiatric and neurodevelopmental diseases.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000410902200002
%$ pmid:28112043
%R 10.1080/15622975.2016.1268715
%U https://juser.fz-juelich.de/record/828033